Utility of shear wave speed measurement to diagnose metastatic lymph node of head and neck squamous cell carcinoma

• Project/Area Number: 16K20246
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Tottori University
• Principal Investigator: FUKUHARA TAKAHIRO 鳥取大学, 医学部, 講師 (80403418)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 頭頸部癌 / 超音波 / 頸部リンパ節転移 / ARFI / shear wave / エラストグラフィ / 頸部リンパ節転移診断 / リンパ節転移 / shear wave エラストグラフィ / shear wave elastography

Outline of Final Research Achievements

First, we evaluated the utility of shear wave elastography as an adjunct to diagnose lymph node metastasis of head and neck cancer. The results showed that the shear wave velocities of around 35% of metastatic lymph nodes could be measured in vivo. We, therefore, focused on strain imaging using acoustic radiation force impulse (ARFI) in the next phase. Secondly, we clarified that the novel strain imaging namely ARFI imaging has high sensitivity and high specificity to diagnose metastatic lymph node of head and neck squamous cell carcinoma. The ARFI imaging also showed high reproducibility. Then we invented a new scoring system of the ARFI imaging to diagnose metastatic lymph node of head and neck cancer and clarified the correlation between the images of each score and the pathological structure of metastatic lymph nodes. Finally, our study showed the novel strain imaging (ARFI imaging) is superior to other conventional elastography.

Research Products

• [Journal Article] Usefulness of a Novel Ultrasonographic Classification Based on Anechoic Area Patterns for Differentiating Warthin Tumors from Pleomorphic Adenomas of the Parotid Gland (2018)
  • Author(s): Matsuda E, Fukuhara T, Donishi R, Kawamoto K, Hirooka Y, Takeuchi H.
  • Journal Title: Yonago Acta Medica Volume: 60 Issue: 4 Pages: 220-226
  • DOI: 10.24563/yam.2017.12.002
  • NAID: 120006382841
  • ISSN: 1346-8049
  • Year and Date: 2018-02-05
  • Peer Reviewed / Open Access
• [Journal Article] Suitable Ultrasonographic Approach to Assessing Vocal Cord Movement: Reply. (2018)
  • Author(s): Fukuhara T.
  • Journal Title: World Journal of Surgery Volume: 42 Issue: 4 Pages: 1215-1215
  • DOI: 10.1007/s00268-017-4350-7
  • Peer Reviewed
• [Journal Article] Clinical efficacy of novel elastography using acoustic radiation force impulse (ARFI) for diagnosis of malignant thyroid nodules (2018)
  • Author(s): Fukuhara T, Matsuda E, Donishi R, Koyama S, Miyake N, Fujiwara K, Takeuchi H
  • Journal Title: Laryngoscope Investigative Otolaryngology Volume: 未 Issue: 4 Pages: 319-325
  • DOI: 10.1002/lio2.165
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Lateral Approach to the Assessment of Vocal Cord Movement by Ultrasonography (2017)
  • Author(s): Fukuhara Takahiro、Donishi Ryohei、Matsuda Eriko、Koyama Satoshi、Fujiwara Kazunori、Takeuchi Hiromi
  • Journal Title: World Journal of Surgery Volume: 42 Issue: 1 Pages: 130-136
  • DOI: 10.1007/s00268-017-4151-z
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of ultrasound for assessing the primary tumor of hypopharyngeal carcinoma. (2017)
  • Author(s): Fukuhara T, Matsuda E, Hattori Y, Donishi R, Ehara H, Fujiwara K, Takeuchi H.
  • Journal Title: Laryngoscope Investigative Otolaryngology Volume: 22 Issue: 6 Pages: 190-194
  • DOI: 10.1002/lio2.126
  • Peer Reviewed / Open Access
• [Journal Article] 超音波検査ハンドブック「頭頸部癌診断」 (2016)
  • Author(s): 福原隆宏
  • Journal Title: JOHNS Volume: 32 Pages: 1489-1493
• [Journal Article] 特集「俄然、”超音波”が注目される理由とは」頭頸部がんの経口手術における最新超音波診断装置の有用性 (2016)
  • Author(s): 福原隆宏
  • Journal Title: 月刊新医療 Volume: 43 Pages: 104-107
• [Presentation] 頸部 総論 「頸部超音波診断で観察すべきこと」 (2018)
  • Author(s): 福原隆宏
  • Organizer: 第4回POC超音波研究会
  • Invited
• [Presentation] 新しいエラストグラフィによる頸部リンパ節転移診断 (2018)
  • Author(s): 福原隆宏、堂西亮平、小山哲史、三宅成智、藤原和典、北野博也、竹内裕美
  • Organizer: 頭頸部外科学会
• [Presentation] An investigation of micro metastases of papillary carcinoma in head and neck region (2017)
  • Author(s): Fukuhara T, Matsuda E, Donishi R, Kitano H, Takeuchi H
  • Organizer: The 12th Asia Oceania Thyroid Association Congress
  • Int'l Joint Research
• [Presentation] Small nodule of papillary thyroid carcinoma in nodular hyperplasia visualized by ARFI imaging (2017)
  • Author(s): Matsuda E, Fukuhara T, Donishi R, Kitano H, Takeuchi H
  • Organizer: The 12th Asia Oceania Thyroid Association Congress
  • Int'l Joint Research
• [Presentation] Usuefulness of ultrasound for assessing the primary site of hypopharyngeal carcinoma (2017)
  • Author(s): Fukuhara T, Ehara H, Hattori Y, Matsuda E, Donishi R, Kitano H, Takeuchi H
  • Organizer: 97th Annual Meeting of ABEA
  • Int'l Joint Research
• [Presentation] 当科での頭頸部超音波の若手育成について (2017)
  • Author(s): 福原隆宏、堂西亮平、松田枝里子、藤原和典、北野博也、竹内裕美
  • Organizer: 第118回日本耳鼻咽喉科学会通常総会・学術講演会
• [Presentation] 耳鼻咽喉科機能評価における超音波診断の応用 (2017)
  • Author(s): 福原隆宏、堂西亮平、松田枝里子、竹内裕美
  • Organizer: 日本超音波医学会第90回学術集会
  • Invited
• [Presentation] 腺腫様結節に併発した甲状腺癌診断に対するARFI imagingの有用性 (2017)
  • Author(s): 福原隆宏、松田枝里子、堂西亮平、竹内裕美
  • Organizer: 第38回日本乳腺甲状腺超音波医学会
• [Presentation] 音響放射圧によるエラストグラフィーの頭頸部癌リンパ節転移診断への有用性 (2017)
  • Author(s): 福原隆宏、堂西亮平、小山哲史、三宅成智、藤原和典、竹内裕美
  • Organizer: 第41回日本頭頸部癌学会
• [Presentation] Clinical efficacy of acoustic radiation force impulse (ARFI) imaging in the diagnosis of thyroid nodules (2017)
  • Author(s): Fukuhara T, Matsuda E, Koyama S, Miyake N, Fujiwara K, Kitano H, Takeuchi H
  • Organizer: 3rd World Congress of Thyroid Cancer
  • Int'l Joint Research
• [Presentation] ARFI elastography (ARFI imaging) for diagnosing cervical lymph node metastasis from head and neck squamous cell carcinoma (2017)
  • Author(s): Fukuhara T
  • Organizer: The 16th World Federation for Ultrasound in Medicine and Biology Congress
  • Int'l Joint Research / Invited
• [Presentation] Utility of intraoperative ultrasonography for head and neck surgery (2017)
  • Author(s): Fukuhara T, Donishi R, Matsuda E, Takeuchi H
  • Organizer: The 16th World Federation for Ultrasound in Medicine and Biology Congress
  • Int'l Joint Research / Invited
• [Presentation] ARFIエラストグラフィによる腺腫様結節に合併した小さな甲状腺癌の検出 (2017)
  • Author(s): 福原隆宏、三宅成智、藤原和典、竹内裕美
  • Organizer: 第50回甲状腺外科学会
• [Presentation] Elastography for differentiating thyroid nodules (2017)
  • Author(s): Fukuhara T, Miyake N, Koyama S, Fujiwara K, Kitano H, Takeuchi H
  • Organizer: 2nd Congress of Asia-Pacific Society of Thyroid Surgery
  • Int'l Joint Research / Invited
• [Presentation] ENT- Head and Neck Ultrasonography in Taiwan and Japan (2017)
  • Author(s): Fukuhara T
  • Organizer: 19th Annual Meeting of Japan Study Group for Head and Neck Ultrasonography
  • Int'l Joint Research / Invited
• [Presentation] Novel techniques for head and neck ultrasonography (2017)
  • Author(s): Fukuhara T, Donishi R, Fujiwara K, Kitano H, Takeuchi H
  • Organizer: 14th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery
  • Int'l Joint Research / Invited
• [Presentation] 頭頸部領域での超音波検査の活用法～超音波エラストグラフィによる頭頸部がん診断～ (2016)
  • Author(s): 福原隆宏
  • Organizer: 第17回大山腫瘍カンファレンス
  • Place of Presentation: 全日空ホテル（米子市）
  • Year and Date: 2016-11-24
• [Presentation] ARFI imagingによる甲状腺結節診断の有用性とshear wave elastographyとの関連性 (2016)
  • Author(s): 福原隆宏
  • Organizer: 第49回日本甲状腺外科学会
  • Place of Presentation: 甲府富士屋ホテル（甲府市）
  • Year and Date: 2016-10-27
• [Presentation] ARFI imagingによって病変が明らかとなった甲状腺乳頭癌症例 (2016)
  • Author(s): 福原隆宏
  • Organizer: 第49回日本甲状腺外科学会
  • Place of Presentation: 甲府富士屋ホテル（甲府市）
  • Year and Date: 2016-10-27
• [Presentation] 頭頸部癌リンパ節転移診断におけるARFI imagingの有用性の検証（予備試験） (2016)
  • Author(s): 福原隆宏
  • Organizer: 第37回日本乳腺甲状腺超音波医学会
  • Place of Presentation: ウェスタ川越（川越市）
  • Year and Date: 2016-10-15
  • Invited
• [Presentation] 甲状腺におけるshear wave elastographyのアーチファクトの解明 (2016)
  • Author(s): 福原隆宏
  • Organizer: 第37回日本乳腺甲状腺超音波医学会
  • Place of Presentation: ウェスタ川越（川越市）
  • Year and Date: 2016-10-15
  • Invited
• [Presentation] ARFI imagingによって明瞭に描出された甲状腺乳頭癌症例 (2016)
  • Author(s): 松田枝里子
  • Organizer: 第37回日本乳腺甲状腺超音波医学会
  • Place of Presentation: ウェスタ川越（川越市）
  • Year and Date: 2016-10-15
  • Invited
• [Presentation] Assessment of artifacts in the measurement of shear wave velocity in the thyroid by comparing in vivo and ex vivo results (2016)
  • Author(s): 福原隆宏
  • Organizer: 86th Annual Meeting of The American Thyroid Association
  • Place of Presentation: Sheraton Denver Downtown Hotel (Denver)
  • Year and Date: 2016-09-24
  • Int'l Joint Research
• [Presentation] Optimal measurement of shear wave velocity in the thyroid: axial versus sagittal direction (2016)
  • Author(s): 松田枝里子
  • Organizer: 86th Annual Meeting of The American Thyroid Association
  • Place of Presentation: Sheraton Denver Downtown Hotel (Denver)
  • Year and Date: 2016-09-24
  • Int'l Joint Research
• [Presentation] 講演３「頭頸部超音波検査の臨床」 (2016)
  • Author(s): 福原隆宏
  • Organizer: 第41回耳鼻咽喉科臨床家フォーラム中四国フォーラム
  • Place of Presentation: 海峡メッセ下関（下関市）
  • Year and Date: 2016-09-18
  • Invited
• [Presentation] 超音波エラストグラフィによる頭頸部癌リンパ節転移診断 (2016)
  • Author(s): 福原隆宏
  • Organizer: 第16回大山腫瘍カンファレンス
  • Place of Presentation: 全日空ホテル（米子市）
  • Year and Date: 2016-09-08
• [Presentation] 甲状腺結節良悪性診断における用手圧迫エラスト グラフィーと A R F I エラストグラフィーの診断精度の比較 (2016)
  • Author(s): 福原隆宏
  • Organizer: 日本超音波医学会第52回中国地方会
  • Place of Presentation: ビックハート出雲（出雲市）
  • Year and Date: 2016-09-03
• [Presentation] 甲状腺における Shear wave elastography の 測定方向による違い (2016)
  • Author(s): 松田枝里子
  • Organizer: 日本超音波医学会第52回中国地方会
  • Place of Presentation: ビックハート出雲（出雲市）
  • Year and Date: 2016-09-03
• [Presentation] 頭頸部の超音波 (2016)
  • Author(s): 福原隆宏
  • Organizer: 第54回鳥取県地方部会学術集会
  • Place of Presentation: 鳥取大学医学部（米子市）
  • Year and Date: 2016-07-24
  • Invited
• [Presentation] Utility of a new type of elastography using acoustic radiation force impulse for diagnosing metastatic lymph nodes from head and neck squamous cell carcinoma: a preliminary study (2016)
  • Author(s): 福原隆宏
  • Organizer: AHNS 9th International Conference on Head and Neck cancer
  • Place of Presentation: Washington State Convention Center (Seattle)
  • Year and Date: 2016-07-20
  • Int'l Joint Research
• [Presentation] 頭頸部領域での超音波検査の活用法～頸部リンパ節診断におけるARFIエラストグラフィーの有用性～ (2016)
  • Author(s): 福原隆宏
  • Organizer: 第36回日本乳腺甲状線超音波医学会学術集会
  • Place of Presentation: グランドプリンスホテル京都（京都市）
  • Year and Date: 2016-05-29
  • Invited
• [Presentation] 音響放射圧によるエラストグラフィーの頭頸部癌リンパ節転移診断への有用性 (2016)
  • Author(s): 福原隆宏
  • Organizer: 日本超音波医学会第89回学術集会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-05-28
  • Invited
• [Presentation] 頭頸部領域の超音波検査 (2016)
  • Author(s): 福原隆宏
  • Organizer: 日本超音波医学会第89回学術集会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-05-28
  • Invited
• [Presentation] Verification of artifacts in the measurement of shear wave velocity in the thyroid (2016)
  • Author(s): 福原隆宏
  • Organizer: The 12th Congress of the Asian Federation of societies for Ultrasound in Medicine & Biology
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-05-28
  • Int'l Joint Research / Invited