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Utility of shear wave speed measurement to diagnose metastatic lymph node of head and neck squamous cell carcinoma

Research Project

Project/Area Number 16K20246
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionTottori University

Principal Investigator

FUKUHARA TAKAHIRO  鳥取大学, 医学部, 講師 (80403418)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords頭頸部癌 / 超音波 / 頸部リンパ節転移 / ARFI / shear wave / エラストグラフィ / 頸部リンパ節転移診断 / リンパ節転移 / shear wave エラストグラフィ / shear wave elastography
Outline of Final Research Achievements

First, we evaluated the utility of shear wave elastography as an adjunct to diagnose lymph node metastasis of head and neck cancer. The results showed that the shear wave velocities of around 35% of metastatic lymph nodes could be measured in vivo. We, therefore, focused on strain imaging using acoustic radiation force impulse (ARFI) in the next phase. Secondly, we clarified that the novel strain imaging namely ARFI imaging has high sensitivity and high specificity to diagnose metastatic lymph node of head and neck squamous cell carcinoma. The ARFI imaging also showed high reproducibility. Then we invented a new scoring system of the ARFI imaging to diagnose metastatic lymph node of head and neck cancer and clarified the correlation between the images of each score and the pathological structure of metastatic lymph nodes. Finally, our study showed the novel strain imaging (ARFI imaging) is superior to other conventional elastography.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (41 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (34 results) (of which Int'l Joint Research: 13 results,  Invited: 16 results)

  • [Journal Article] Usefulness of a Novel Ultrasonographic Classification Based on Anechoic Area Patterns for Differentiating Warthin Tumors from Pleomorphic Adenomas of the Parotid Gland2018

    • Author(s)
      Matsuda E, Fukuhara T, Donishi R, Kawamoto K, Hirooka Y, Takeuchi H.
    • Journal Title

      Yonago Acta Medica

      Volume: 60 Issue: 4 Pages: 220-226

    • DOI

      10.24563/yam.2017.12.002

    • NAID

      120006382841

    • ISSN
      1346-8049
    • Year and Date
      2018-02-05
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suitable Ultrasonographic Approach to Assessing Vocal Cord Movement: Reply.2018

    • Author(s)
      Fukuhara T.
    • Journal Title

      World Journal of Surgery

      Volume: 42 Issue: 4 Pages: 1215-1215

    • DOI

      10.1007/s00268-017-4350-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of novel elastography using acoustic radiation force impulse (ARFI) for diagnosis of malignant thyroid nodules2018

    • Author(s)
      Fukuhara T, Matsuda E, Donishi R, Koyama S, Miyake N, Fujiwara K, Takeuchi H
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 未 Issue: 4 Pages: 319-325

    • DOI

      10.1002/lio2.165

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Lateral Approach to the Assessment of Vocal Cord Movement by Ultrasonography2017

    • Author(s)
      Fukuhara Takahiro、Donishi Ryohei、Matsuda Eriko、Koyama Satoshi、Fujiwara Kazunori、Takeuchi Hiromi
    • Journal Title

      World Journal of Surgery

      Volume: 42 Issue: 1 Pages: 130-136

    • DOI

      10.1007/s00268-017-4151-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of ultrasound for assessing the primary tumor of hypopharyngeal carcinoma.2017

    • Author(s)
      Fukuhara T, Matsuda E, Hattori Y, Donishi R, Ehara H, Fujiwara K, Takeuchi H.
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 22 Issue: 6 Pages: 190-194

    • DOI

      10.1002/lio2.126

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 超音波検査ハンドブック「頭頸部癌診断」2016

    • Author(s)
      福原隆宏
    • Journal Title

      JOHNS

      Volume: 32 Pages: 1489-1493

    • Related Report
      2016 Research-status Report
  • [Journal Article] 特集「俄然、”超音波”が注目される理由とは」頭頸部がんの経口手術における最新超音波診断装置の有用性2016

    • Author(s)
      福原隆宏
    • Journal Title

      月刊新医療

      Volume: 43 Pages: 104-107

    • Related Report
      2016 Research-status Report
  • [Presentation] 頸部 総論 「頸部超音波診断で観察すべきこと」2018

    • Author(s)
      福原隆宏
    • Organizer
      第4回POC超音波研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 新しいエラストグラフィによる頸部リンパ節転移診断2018

    • Author(s)
      福原隆宏、堂西亮平、小山哲史、三宅成智、藤原和典、北野博也、竹内裕美
    • Organizer
      頭頸部外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] An investigation of micro metastases of papillary carcinoma in head and neck region2017

    • Author(s)
      Fukuhara T, Matsuda E, Donishi R, Kitano H, Takeuchi H
    • Organizer
      The 12th Asia Oceania Thyroid Association Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Small nodule of papillary thyroid carcinoma in nodular hyperplasia visualized by ARFI imaging2017

    • Author(s)
      Matsuda E, Fukuhara T, Donishi R, Kitano H, Takeuchi H
    • Organizer
      The 12th Asia Oceania Thyroid Association Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Usuefulness of ultrasound for assessing the primary site of hypopharyngeal carcinoma2017

    • Author(s)
      Fukuhara T, Ehara H, Hattori Y, Matsuda E, Donishi R, Kitano H, Takeuchi H
    • Organizer
      97th Annual Meeting of ABEA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 当科での頭頸部超音波の若手育成について2017

    • Author(s)
      福原隆宏、堂西亮平、松田枝里子、藤原和典、北野博也、竹内裕美
    • Organizer
      第118回日本耳鼻咽喉科学会通常総会・学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 耳鼻咽喉科機能評価における超音波診断の応用2017

    • Author(s)
      福原隆宏、堂西亮平、松田枝里子、竹内裕美
    • Organizer
      日本超音波医学会第90回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 腺腫様結節に併発した甲状腺癌診断に対するARFI imagingの有用性2017

    • Author(s)
      福原隆宏、松田枝里子、堂西亮平、竹内裕美
    • Organizer
      第38回日本乳腺甲状腺超音波医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 音響放射圧によるエラストグラフィーの頭頸部癌リンパ節転移診断への有用性2017

    • Author(s)
      福原隆宏、堂西亮平、小山哲史、三宅成智、藤原和典、竹内裕美
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Clinical efficacy of acoustic radiation force impulse (ARFI) imaging in the diagnosis of thyroid nodules2017

    • Author(s)
      Fukuhara T, Matsuda E, Koyama S, Miyake N, Fujiwara K, Kitano H, Takeuchi H
    • Organizer
      3rd World Congress of Thyroid Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ARFI elastography (ARFI imaging) for diagnosing cervical lymph node metastasis from head and neck squamous cell carcinoma2017

    • Author(s)
      Fukuhara T
    • Organizer
      The 16th World Federation for Ultrasound in Medicine and Biology Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Utility of intraoperative ultrasonography for head and neck surgery2017

    • Author(s)
      Fukuhara T, Donishi R, Matsuda E, Takeuchi H
    • Organizer
      The 16th World Federation for Ultrasound in Medicine and Biology Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ARFIエラストグラフィによる腺腫様結節に合併した小さな甲状腺癌の検出2017

    • Author(s)
      福原隆宏、三宅成智、藤原和典、竹内裕美
    • Organizer
      第50回甲状腺外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Elastography for differentiating thyroid nodules2017

    • Author(s)
      Fukuhara T, Miyake N, Koyama S, Fujiwara K, Kitano H, Takeuchi H
    • Organizer
      2nd Congress of Asia-Pacific Society of Thyroid Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ENT- Head and Neck Ultrasonography in Taiwan and Japan2017

    • Author(s)
      Fukuhara T
    • Organizer
      19th Annual Meeting of Japan Study Group for Head and Neck Ultrasonography
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel techniques for head and neck ultrasonography2017

    • Author(s)
      Fukuhara T, Donishi R, Fujiwara K, Kitano H, Takeuchi H
    • Organizer
      14th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 頭頸部領域での超音波検査の活用法~超音波エラストグラフィによる頭頸部がん診断~2016

    • Author(s)
      福原隆宏
    • Organizer
      第17回大山腫瘍カンファレンス
    • Place of Presentation
      全日空ホテル(米子市)
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ARFI imagingによる甲状腺結節診断の有用性とshear wave elastographyとの関連性2016

    • Author(s)
      福原隆宏
    • Organizer
      第49回日本甲状腺外科学会
    • Place of Presentation
      甲府富士屋ホテル(甲府市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] ARFI imagingによって病変が明らかとなった甲状腺乳頭癌症例2016

    • Author(s)
      福原隆宏
    • Organizer
      第49回日本甲状腺外科学会
    • Place of Presentation
      甲府富士屋ホテル(甲府市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 頭頸部癌リンパ節転移診断におけるARFI imagingの有用性の検証(予備試験)2016

    • Author(s)
      福原隆宏
    • Organizer
      第37回日本乳腺甲状腺超音波医学会
    • Place of Presentation
      ウェスタ川越(川越市)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 甲状腺におけるshear wave elastographyのアーチファクトの解明2016

    • Author(s)
      福原隆宏
    • Organizer
      第37回日本乳腺甲状腺超音波医学会
    • Place of Presentation
      ウェスタ川越(川越市)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ARFI imagingによって明瞭に描出された甲状腺乳頭癌症例2016

    • Author(s)
      松田枝里子
    • Organizer
      第37回日本乳腺甲状腺超音波医学会
    • Place of Presentation
      ウェスタ川越(川越市)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Assessment of artifacts in the measurement of shear wave velocity in the thyroid by comparing in vivo and ex vivo results2016

    • Author(s)
      福原隆宏
    • Organizer
      86th Annual Meeting of The American Thyroid Association
    • Place of Presentation
      Sheraton Denver Downtown Hotel (Denver)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optimal measurement of shear wave velocity in the thyroid: axial versus sagittal direction2016

    • Author(s)
      松田枝里子
    • Organizer
      86th Annual Meeting of The American Thyroid Association
    • Place of Presentation
      Sheraton Denver Downtown Hotel (Denver)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 講演3「頭頸部超音波検査の臨床」2016

    • Author(s)
      福原隆宏
    • Organizer
      第41回耳鼻咽喉科臨床家フォーラム中四国フォーラム
    • Place of Presentation
      海峡メッセ下関(下関市)
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 超音波エラストグラフィによる頭頸部癌リンパ節転移診断2016

    • Author(s)
      福原隆宏
    • Organizer
      第16回大山腫瘍カンファレンス
    • Place of Presentation
      全日空ホテル(米子市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 甲状腺結節良悪性診断における用手圧迫エラスト グラフィーと A R F I エラストグラフィーの診断精度の比較2016

    • Author(s)
      福原隆宏
    • Organizer
      日本超音波医学会第52回中国地方会
    • Place of Presentation
      ビックハート出雲(出雲市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 甲状腺における Shear wave elastography の 測定方向による違い2016

    • Author(s)
      松田枝里子
    • Organizer
      日本超音波医学会第52回中国地方会
    • Place of Presentation
      ビックハート出雲(出雲市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 頭頸部の超音波2016

    • Author(s)
      福原隆宏
    • Organizer
      第54回鳥取県地方部会学術集会
    • Place of Presentation
      鳥取大学医学部(米子市)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Utility of a new type of elastography using acoustic radiation force impulse for diagnosing metastatic lymph nodes from head and neck squamous cell carcinoma: a preliminary study2016

    • Author(s)
      福原隆宏
    • Organizer
      AHNS 9th International Conference on Head and Neck cancer
    • Place of Presentation
      Washington State Convention Center (Seattle)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頭頸部領域での超音波検査の活用法~頸部リンパ節診断におけるARFIエラストグラフィーの有用性~2016

    • Author(s)
      福原隆宏
    • Organizer
      第36回日本乳腺甲状線超音波医学会学術集会
    • Place of Presentation
      グランドプリンスホテル京都(京都市)
    • Year and Date
      2016-05-29
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 音響放射圧によるエラストグラフィーの頭頸部癌リンパ節転移診断への有用性2016

    • Author(s)
      福原隆宏
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 頭頸部領域の超音波検査2016

    • Author(s)
      福原隆宏
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Verification of artifacts in the measurement of shear wave velocity in the thyroid2016

    • Author(s)
      福原隆宏
    • Organizer
      The 12th Congress of the Asian Federation of societies for Ultrasound in Medicine & Biology
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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