Prevention of age-related hearing loss through Sirt1 stabilization via MNAM

Research Project

Project/Area Number	16K20257
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Kumamoto University
Principal Investigator	Kusaba Yuki 熊本大学, 病院, 非常勤診療医師 (70648592)
Project Period (FY)	2016-04-01 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	加齢性難聴 / Sirt1 / MNAM / 高脂肪食負荷 / 基礎医学
Outline of Final Research Achievements	Age-related hearing loss was prevented in the MNAM group compared to control group. Sirt1 expression was reduced in the control group compared to MNAM group. Sirt1 expression was prevented from the decrease in MNAM group.
Academic Significance and Societal Importance of the Research Achievements	新しいSirt1安定化メカニズムを惹起する薬剤を用いて加齢性難聴を予防することを可能とした。今後、ヒトに応用されれば加齢性難聴発症を予防できる可能性がある。