Pathogenic mechanism of otitis media with ANCA associated vasculitis and development of a diagnostic algorithm for early diagnosis

• Project/Area Number: 16K20262
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Oita University
• Principal Investigator: Tateyama Kaori 大分大学, 医学部, 病院特任助教 (00771958)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 抗好中球細胞質抗体 / ANCA関連血管炎 / ANCA陰性 / ANCA関連血管炎性中耳炎 / 抗LAMP2抗体 / 中耳炎 / 中耳貯留液 / minor ANCA / 抗LAMP-2抗体

Outline of Final Research Achievements

ANCA (anti-neutrophil cytoplasmic antibody) -associated vasculitis is a disease that causes life threatening organ dysfunction as a result of inflammation mainly in small blood vessels of the whole body. Initial symptom is often seen in ear, nose and throat lesions such as refractory otitis media that complicates irreversible hearing loss and facial nerve paralysis and necrotizing lesions of the nasal mucosa that leads to saddle nose (low nose). However, in the early stage, ANCA which is useful for diagnosis is negative and it is often difficult to diagnose. In this study, we developed and proposed an algorithm of the examination method for early diagnosis of this disease using various ANCA measurement methods. In order to clarify the pathology of the disease, a study was conducted to prove the involvement of bacterial infection in the middle ear, which triggers the onset of the disease.

Research Products

• [Journal Article] ANCA関連血管炎性中耳炎の寛解導入治療後の聴力経過 (2018)
  • Author(s): 立山香織、児玉悟、渡辺哲夫、平野隆、川野利明、梅本真吾、鈴木正志
  • Journal Title: Otology Japan Volume: 28 Pages: 19-24
  • NAID: 130007504400
  • Peer Reviewed
• [Journal Article] ANCA関連血管炎性中耳炎と肥厚性硬膜炎 (2018)
  • Author(s): 立山香織
  • Journal Title: ENTONI Volume: 217 Pages: 47-51
• [Journal Article] ANCA関連血管炎性中耳炎（OMAAV） (2017)
  • Author(s): 立山香織
  • Journal Title: アレルギーと臨床 Volume: 37 Pages: 40-44
• [Journal Article] A novel strategy with combined assays for detection of anti-neutrophil cytoplasmic antibody (ANCA) in clinically ANCA-negative granulomatosis with polyangiitis patients (2017)
  • Author(s): Tateyama K, Kodama S, Kishibe K, Harabuchi Y, Suzuki M
  • Journal Title: AURIS NASUS LARYNX Volume: in press
  • NAID: 130007474921
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ANCA関連血管炎性中耳炎全国調査ワーキンググルーブ報告 ANCA関連血管炎性中耳炎(Otitis media with ANCA-associated vasculitis:OMAAV)診断基準2015とその解説(解説) (2016)
  • Author(s): 吉田 尚弘, 原渕 保明, 岸部 幹, 立山 香織, 森田 由香, 坂口 博史, 長谷川 賢作, 國本 泰臣, 松井 隆道, 岡田 昌浩, 渡邊 毅, 稲垣 彰, 村上 信五, 高橋 晴雄, 東野 哲也, 小林 茂人, 飯野 ゆき子, ANCA関連血管炎性中耳炎全国調査ワーキンググループ
  • Journal Title: Otology Japan Volume: 26 Pages: 37-39
• [Journal Article] Clinical features and treatment outcomes of otitis media with antieutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): a retrospective analysis of 235 patients from a nationwide survey in Japan. (2016)
  • Author(s): Harabuchi Y, Kishibe K, Tateyama K, Morita Y, Yoshida N, Kunimoto Y, Matusi T, Sakaguchi H, Okada M, Watanabe T, Inagaki A, Kobayashi S, Iino Y, Murakami S, Takahashi H, Tono T
  • Journal Title: Modern Rheumatology Volume: Early Online Issue: 1 Pages: 1-7
  • DOI: 10.1080/14397595.2016.1177926
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Clinical differences of otitis media with ANCA-associated vasculitis based on the type of ANCAs: a retrospective multi-center study in Japan (2017)
  • Author(s): Kaori Tateyama, Naohiro Yoshida, Kan Kishibe, Yuka Morita, Yasuyuki Harabuchi, OMAAV working group of the Japan Otological Society
  • Organizer: 第18回 International Vasculitis & ANCA Workshop (Vasculitis 2017)
  • Int'l Joint Research
• [Presentation] ANCA関連血管炎性中耳炎における抗LAMP-2抗体発現 (2017)
  • Author(s): 立山香織、平野隆、鈴木正志、岸部幹、原渕保明
  • Organizer: 第35回日本耳鼻咽喉科免疫アレルギー学会
• [Presentation] Relationship between minor antineutrophil cytoplasmic antibody (ANCA) and otitis media with ANCA-associated vasculitis (2017)
  • Author(s): Kaori Tateyama, Takashi Hirano, Satoru Kodama, Masashi Suzuki, Kan Kishibe, Yasuaki Harabuchi
  • Organizer: 19th International Symposium on Recent Advances in Otitis Media (RAOM 2017)
  • Int'l Joint Research
• [Presentation] ANCA関連血管炎性中耳炎のトリガーにおける細菌感染の関与 -中耳貯留液の細菌学的検討- (2017)
  • Author(s): 立山香織、川野利明、平野隆、岸部幹、岡田昌浩、太田有美、福井英人、原渕保明、鈴木正志
  • Organizer: 第27回耳科学会総会・学術講演会
• [Presentation] ANCA関連血管炎性中耳炎の治療後聴力経過と予後 ―突発性難聴との比較検討― (2016)
  • Author(s): 立山香織、平野隆、渡辺哲生、鈴木正志
  • Organizer: 第26回日本耳科学会総会・学術講演会
  • Place of Presentation: ホテル国際21（長野県、長野市）
  • Year and Date: 2016-10-05
• [Presentation] ANCA関連血管炎におけるminor ANCA測定の意義 (2016)
  • Author(s): 立山香織、児玉悟)、鈴木正志、國本泰臣、岸部幹、原渕保明
  • Organizer: 第117回日本耳鼻咽喉科学会通常総会・学術講演会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2016-05-18
• [Book] ANCA関連血管炎中耳炎(OMAAV)診療の手引き (2016)
  • Author(s): 原渕 保明, 吉田 尚弘, 岸部 幹, 立山 香織, 森田 由香, 坂口 博史, 長谷川 賢作, 國本 泰臣, 松井 隆道, 岡田 昌浩, 渡邊 毅, 稲垣 彰, 村上信五, 高橋 晴雄, 東野 哲也,小林 茂人, 飯野 ゆき子,
  • Total Pages: 109
  • Publisher: 金原出版