| Project/Area Number |
16K20280
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 鼻ポリープ / 副鼻腔炎 / 培養系細胞の確立 / サイトカイン / 分泌応答 / 網羅的解析 / 免疫応答プロファイル / 副ポリープ / IL-17 |
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| Outline of Final Research Achievements |
Chronic rhinosinusitis (CRS) is defined as persistent inflammation of the nasal and paranasal cavity mucosa lasting ³3 months. In the present study, we examined the level of cytokine and chemokine release from the nasal polyp fibroblasts and its effect on IL-17A in order to clarify the functional role of fibroblasts in chronic inflammatory responses in the upper airway. Even without inflammatory stimulation, the secretions of MCP-1 were 33.3-fold and 22.2-fold higher in the eosinophilic group and non-eosinophilic group, respectively, compared to the control group. There was a marked release of IL-6 from nasal polyp fibroblasts of the eosinophilic group, which was significantly greater than those of the control and non-eosinophilic groups. However, there was no difference in IL-6 secretion between the control and non-eosinophilic groups. Thus, the cytokines and chemokines released from the nasal polyp fibroblasts may be related to local airway inflammation.
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