Study on the effect of low estrogen to olfactory epithelial in mice
| Project/Area Number |
16K20284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 感冒後嗅覚障害 / エストロゲン / 嗅上皮 / 嗅上皮再生 / 卵巣摘出術 / OMP / Ki-67 / 嗅覚 / 感冒罹患後 / メチマゾール |
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| Outline of Final Research Achievements |
At the 6W after ip methimazole, OVX and Sham-ope groups recovered to the same OMP and Ki-67 positive cell rate. The OMP and Ki-67 positive cell rate was significantly lower in the OVX group at only 2W after ip methimazole.The olfactory epithelium also recover in the low estrogen state by ovariectomy.However, it was suggested that the low estrogen state delay the recover speed of the olfactory epithelium at an early stage after damage.
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Report
(3 results)
Research Products
(5 results)
