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Study on the effect of low estrogen to olfactory epithelial in mice

Research Project

Project/Area Number 16K20284
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKanazawa Medical University

Principal Investigator

YAMADA Kentaro  金沢医科大学, 医学部, 助教 (60722642)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords感冒後嗅覚障害 / エストロゲン / 嗅上皮 / 嗅上皮再生 / 卵巣摘出術 / OMP / Ki-67 / 嗅覚 / 感冒罹患後 / メチマゾール
Outline of Final Research Achievements

At the 6W after ip methimazole, OVX and Sham-ope groups recovered to the same OMP and Ki-67 positive cell rate. The OMP and Ki-67 positive cell rate was significantly lower in the OVX group at only 2W after ip methimazole.The olfactory epithelium also recover in the low estrogen state by ovariectomy.However, it was suggested that the low estrogen state delay the recover speed of the olfactory epithelium at an early stage after damage.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017

All Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Gender differences and influences to olfactory nerve regeneration by ovariectomy in mice2018

    • Author(s)
      Kentaro Yamada Takuya Noda  Hideaki Shiga Hideaki NInomiya Takaki MIwa
    • Organizer
      27th Congress of the European Rhinologic Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 卵巣摘出マウスにおける嗅上皮障害後の嗅上皮再生に関する研究2018

    • Author(s)
      山田健太郎 能田拓也 石倉友子 中村有加里 志賀英明  二宮英明  三輪高喜
    • Organizer
      第36回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 低エストロゲンがマウス嗅上皮 に及ぼす影響に関する研究2017

    • Author(s)
      山田健太郎
    • Organizer
      第35回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      旭川グランドホテル(北海道旭川市)
    • Year and Date
      2017-04-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 嗅神経性嗅覚障害の病態解明と治療への応用2017

    • Author(s)
      山田健太郎 能田拓也 石倉友子 中村有加里 志賀英明  二宮英明  三輪高喜
    • Organizer
      第56回日本耳鼻咽喉科鼻科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of ovariecotmy on regeneration of olfactory neuron in mice2017

    • Author(s)
      Kentaro Yamada Takuya Noda  Hideaki Shiga Hideaki NInomiya Takaki MIwa
    • Organizer
      Rhinology World Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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