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A new approach for detection of early phryngeal cancer

Research Project

Project/Area Number 16K20289
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

Morita Shinkichi  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (10773955)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords咽頭癌 / 下咽頭癌 / 下咽頭がん / 早期診断 / うがい液
Outline of Final Research Achievements

In this study, to develop a new diagnosis method for early pharyngeal cancer and a new therapy, we tried to find a new diagnostic marker. We screened a high tumorigenic population of PDX-derived hypopharyngeal cancer in tumorigenic activity assay using immunodeficient NOG mice. We found that CD271high population possessed significantly high tumorigenic activity than CD271low population. To identify CD271 as a therapeutic target, we developed 5 clones of anti-CD271 antibodies. Among several clones, we chose one clone to humanize since this clone possessed highest affinity against CD271. We injected the humanized antibody with effector cells into cancer cell-xenografted mice, and found that tumor volume was significantly suppressed in the antibody-injected mice than vehicle-injected mice.

Academic Significance and Societal Importance of the Research Achievements

本研究は難治である下咽頭癌に対して、新たな表面マーカーおよび治療標的を同定することができた。これまで、咽頭癌には特異的な治療標的が乏しく、今回新たに発見された意義は大きい。また、ヒト化抗体を用いて腫瘍抑制効果があることが確認できたため、臨床応用の期待ができる。今後、CD271の機能解析を含め、引き続き研究を実施する。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Myeloid Sarcoma of the Paranasal Sinuses in a Patient with Acute Myeloid Leukemia2018

    • Author(s)
      Suzuki Jun、Harazaki Yoriko、Morita Shinkichi、Kaga Yoshiko、Nomura Kazuhiro、Sugawara Mitsuru、Katori Yukio
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 246 Issue: 2 Pages: 141-146

    • DOI

      10.1620/tjem.246.141

    • NAID

      130007501633

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2016-04-21   Modified: 2021-01-27  

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