glaucoma treatment approach from oxidative stress
| Project/Area Number |
16K20299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 緑内障 / 酸化ストレス / 神経保護 / 網膜神経節細胞 / 抗酸化力 |
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| Outline of Final Research Achievements |
Some recent clinical and basic reports on oxidative stress in glaucoma. Oxidative stress is correlated with blood flow in all groups and is especially highly correlated in early NTG （Graefes Arch Clin Exp Ophthalmol. 2016）. Our research focused on BAP and wrgc, specific measures of antioxidant potential and RGC survival, in OAG patients younger than 65 years（Sci Rep. 2017.）. We also reveal that glaucoma patients with SAS had a steeper MD slope than patients without SAS, and that the incidence of SAS was highest in the glaucoma patients with the fastest progression（Acta Ophthalmol. 2018）.
These results suggested that anti-oxidant therapy might be more effective in glaucoma patients.
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Report
(3 results)
Research Products
(10 results)
