glaucoma treatment approach from oxidative stress

• Project/Area Number: 16K20299
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Tohoku University
• Principal Investigator: Himori Noriko 東北大学, 大学病院, 助教 (20705230)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 緑内障 / 酸化ストレス / 神経保護 / 網膜神経節細胞 / 抗酸化力

Outline of Final Research Achievements

Some recent clinical and basic reports on oxidative stress in glaucoma. Oxidative stress is correlated with blood flow in all groups and is especially highly correlated in early NTG （Graefes Arch Clin Exp Ophthalmol. 2016）. Our research focused on BAP and wrgc, specific measures of antioxidant potential and RGC survival, in OAG patients younger than 65 years（Sci Rep. 2017.）. We also reveal that glaucoma patients with SAS had a steeper MD slope than patients without SAS, and that the incidence of SAS was highest in the glaucoma patients with the fastest progression（Acta Ophthalmol. 2018）.
These results suggested that anti-oxidant therapy might be more effective in glaucoma patients.

Research Products

• [Journal Article] The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnea syndrome. (2018)
  • Author(s): Yamada E, Himori H, Kunikata H, Omodaka K, Ogawa H, Ichinose M, Nakazawa T
  • Journal Title: Acta Ophthalmologica Volume: 印刷中 Issue: 4
  • DOI: 10.1111/aos.13693
  • Peer Reviewed / Open Access
• [Journal Article] Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage. (2017)
  • Author(s): Yoshimi Asano, Noriko Himori, Hiroshi Kunikata, Mai Yamazaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, and Toru Nakazawa
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 8032-8032
  • DOI: 10.1038/s41598-017-08624-4
  • Peer Reviewed / Open Access
• [Journal Article] The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma. (2017)
  • Author(s): Himori N, Kunikata H, Kawasaki R, Shiga Y, Omodaka K, Takahashi H, Miyata T, Nakazawa T.
  • Journal Title: Br J Ophthalmol. Volume: 101 Issue: 2 Pages: 233-238
  • DOI: 10.1136/bjophthalmol-2016-309504
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Optic nerve head microcirculation in autosomal dominant optic atrophy and normal-tension glaucoma. (2017)
  • Author(s): Himori N, Kunikata H, Inoue M, Takeshita T, Nishiguchi K, Nakazawa T
  • Journal Title: Acta ophthalmolgica Volume: 印刷中 Issue: 8
  • DOI: 10.1111/aos.13353
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 複合サプリメント摂取による抗酸化力の変動 (2017)
  • Author(s): 檜森紀子、佐藤孝太、中澤徹
  • Organizer: 第28回緑内障学会
• [Presentation] 正常眼圧緑内障患者における皮膚AGEと視神経乳頭網膜神経線維層厚 (2017)
  • Author(s): 檜森紀子、国分太貴、志賀由己浩、面高宗子、國方彦志、中澤徹
  • Organizer: 第71回臨床眼科学会
• [Presentation] The association between oxidative stress and glaucoma (2017)
  • Author(s): Noriko Himori
  • Organizer: Joint conference
• [Presentation] 緑内障患者における酸化ストレスと視野 (2016)
  • Author(s): 檜森紀子、國方彦志、川崎良、志賀由己浩、面高宗子、高木愛理、中澤徹
  • Organizer: 第70回 日本臨床眼科学会
  • Place of Presentation: 京都国際センター（京都）
  • Year and Date: 2016-11-04
• [Presentation] 正常眼圧緑内障患者における酸化ストレスマーカーと視神経乳頭循環との関連 (2016)
  • Author(s): 檜森紀子、志賀由己浩、面高宗子、國方彦志、中澤徹
  • Organizer: 第69回酸化ストレス学会
  • Place of Presentation: 仙台国際センター（仙台）
  • Year and Date: 2016-08-31
• [Presentation] 緑内障患者における酸化ストレスと抗酸化力 (2016)
  • Author(s): 檜森紀子、志賀由己浩、面高宗子、國方彦志、高木愛梨、川崎良、中澤徹
  • Organizer: 第120回 日本眼科学会総会
  • Place of Presentation: 仙台国際センター(仙台）
  • Year and Date: 2016-04-07