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Evaluation of non-swelling hydrogel as a intraocular tamponade during vitrectomy for retinal detachment

Research Project

Project/Area Number 16K20303
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Hoshi Sujin  筑波大学, 医学医療系, 講師 (10757892)

Research Collaborator OKAMOTO Fumiki  筑波大学, 医学医療系, 講師 (30334064)
SAKAI Takamasa  東京大学, 大学院・工学系研究科 バイオエンジニアリング専攻, 准教授 (70456151)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords眼内タンポナーデ / 人工硝子体 / 眼毒性 / ハイドロゲル / 分解性 / 網膜硝子体
Outline of Final Research Achievements

We conducted experiments to test intraocular toxicity of non-swelling hydrogel as a intraocular tamponade using rabbit eyes. There was limited postoperative inflammatory response, no intraocular pressue elevation or sign of hydrogel opacity. Retinal microstructure and retinal function was normal. We concluded that this hydrogel could be used safely as a intraocular tamponade. The material we used, however, was non-degradable hydrogel. To establish a sutable material for clinical use, we continue our research to fabricate degradable non-swelling hydrogel and evaluate its safety and feasibility as a intraocular tamponade.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] In vivo feasibility study of an ultralow polymeric content hydrogel as an artificial vitreous body using rabbit eyes2017

    • Author(s)
      星崇仁
    • Organizer
      17th European Society of Retina Specialists Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分解性低ポリマー濃度臨界ハイドロゲル人工硝子体の細胞毒性の検討2017

    • Author(s)
      星崇仁
    • Organizer
      第56回日本網膜硝子体学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel critical hydrogel as an artificial vitreous body2016

    • Author(s)
      星崇仁
    • Organizer
      第55回日本網膜硝子体学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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