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Exploring laser settings and molecular mechanisms of subthreshold retinal photocoagulation for diabetic macular edema

Research Project

Project/Area Number 16K20305
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionThe University of Tokyo

Principal Investigator

ARAKI FUMIYUKI  東京大学, 医学部附属病院, 助教 (20724652)

Research Collaborator SHIRAYA tomoyasu  
KATO satoshi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords閾値下網膜光凝固 / 糖尿病黄斑浮腫 / 網膜閾値下凝固 / 閾値以下網膜光凝固術
Outline of Final Research Achievements

Using a pattern scan laser device, we performed rabbit retina photocoagulation. We estimated the photocoagulation spot size, depth, and elucidated the parameter of subthreshold laser treatment by histological methods.
We assessed the effects of subthreshold laser photocoagulation using a conventional pattern scan laser (PS-STLT) in 24 eyes of 24 patients with macular edema and revealed PS-STLT for the treatment of ME is effective.

Academic Significance and Societal Importance of the Research Achievements

ウサギ網膜を用いた、閾値以下網膜光凝固(SLT)のレーザー設定値の決定により、従来のパターンスキャンレーザー装置でも網膜閾値下凝固術を行うことができる可能性が示唆することができた。
また、実際の黄斑浮腫症例に対してパターンスキャンレーザー装置を用いてSLT治療の解析を行い、、糖尿病黄斑浮腫治療のコスト低減の可能性を示唆することができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Therapeutic Efficacy of Subthreshold Laser Photocoagulation using a Conventional Pattern Scan Laser for Macular Edema in a Retrospective Study2018

    • Author(s)
      Tomoyasu Shiraya、Satoshi Kato、Fumiyuki Araki
    • Journal Title

      International Journal of Ophthalmology and Clinical Research

      Volume: 5 Issue: 3 Pages: 1-8

    • DOI

      10.23937/2378-346x/1410090

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimental verification of subthreshold laser therapy using conventional pattern scan laser2017

    • Author(s)
      Shiraya Tomoyasu、Kato Satoshi、Araki Fumiyuki、Ueta Takashi、Abe Hitoshi、Asai Nobuharu
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 9 Pages: e0184392-e0184392

    • DOI

      10.1371/journal.pone.0184392

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 黄斑浮腫に対するパターンスキャンレーザーを使用した閾値下網膜光凝固術2017

    • Author(s)
      荒木章之
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ウサギを用いた閾値下網膜光凝固術の従来機種への適応の検討2017

    • Author(s)
      白矢智靖
    • Organizer
      第121回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2016 Research-status Report
  • [Presentation] 黄斑浮腫に対するパターンスキャンレーザーを使用した閾値下網膜光凝固術2017

    • Author(s)
      荒木章之
    • Organizer
      第121回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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