The evaluation of correlation between photoreceptor's degeneration and angiopathy in retinal degenerative model mouse.
| Project/Area Number |
16K20319
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
ORITA Tomoko 山口大学, 大学院医学系研究科, 助教 (50467792)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 網膜色素変性 / 視細胞 / 血流障害 / Proml / 血管内皮細胞 / 網膜血管内皮細胞 / Prom1 |
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| Outline of Final Research Achievements |
The histological analysis revealed that the retinal vascular endothelial cells in Prom1 KO mice were smaller than ones in WT. Moreover the density and the length of renal cilia in Prom1 KO are much lower than WT and Prom1 KO mice have hematuria.
The outer segments of photoreceptor in the KO mice were shortened compared with that of WT. This degeneration was initiated after the mice open their eyes, thus it suggested that the light exposure might cause Prom1-mediated photoreceptor degeneration.
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Report
(3 results)
Research Products
(19 results)
