Research Project
Grant-in-Aid for Young Scientists (B)
We investigate the antiangiogenic efficacy of tissue plasminogen activator (tPA) on experimental laser-induced choroidal neovascularization (CNV) in mice. Intravitreal administration of tPA significantly suppressed CNV leakage and CNV volume. Intravitreal injection of tPA suppressed fibrin/fibrinogen and CD31 expression in laser-induced lesions. Histologic examination and electroretinography showed no evidence of retinal toxicy in eyes injected with tPA. The current results suggested that tPA may be a potential therapeutic adjuvant for treating CNV.
All 2016
All Journal Article (1 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 1 results, Open Access: 1 results)
Invest Ophthalmic Vis Sci
Volume: 57 Issue: 13 Pages: 5348-5354
10.1167/iovs.16-19617