Pathogenesis of age-related macular degeneration related to high fat diet
| Project/Area Number |
16K20330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
Tomita Yohei 慶應義塾大学, 医学部(信濃町), 特任助教 (00528200)
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| Research Collaborator |
OZAWA Yoko
TODA Eriko
NAGAI Norihiro
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 高脂肪食 / 網膜 / 加齢 / 加齢黄斑変性 |
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| Outline of Final Research Achievements |
Five-week old male mice were constantly fed either with high fat diet (including 32% fat) or control diet (including 4.6% fat), both of which were commercially available. The body weight and blood sugar levels of the high fat diet-fed mice were increased compared with control diet-fed mice after 3 months, although the animals did not have diabetes. The inflammatory cytokines and macrophage markers were increased in the RPE-choroid samples of the high fat diet-fed mice compared with control diet-fed mice.
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Report
(3 results)
Research Products
(2 results)
