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Pathogenesis of age-related macular degeneration related to high fat diet

Research Project

Project/Area Number 16K20330
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

Tomita Yohei  慶應義塾大学, 医学部(信濃町), 特任助教 (00528200)

Research Collaborator OZAWA Yoko  
TODA Eriko  
NAGAI Norihiro  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords高脂肪食 / 網膜 / 加齢 / 加齢黄斑変性
Outline of Final Research Achievements

Five-week old male mice were constantly fed either with high fat diet (including 32% fat) or control diet (including 4.6% fat), both of which were commercially available. The body weight and blood sugar levels of the high fat diet-fed mice were increased compared with control diet-fed mice after 3 months, although the animals did not have diabetes. The inflammatory cytokines and macrophage markers were increased in the RPE-choroid samples of the high fat diet-fed mice compared with control diet-fed mice.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Functional Visual Acuity in Age-Related Macular Degeneration.2016

    • Author(s)
      Tomita Y, Nagai Y, Suzuki M, Shinoda H, Uchida A, Mochimaru H, Izumi-Nagai K, Sasaki M, Tsubota K, Ozawa Y
    • Journal Title

      Optometry and Vision Science

      Volume: 93 Issue: 1 Pages: 70-76

    • DOI

      10.1097/opx.0000000000000755

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct responsiveness to intravitreal ranibizumab therapy in polypoidal choroidal vasculopathy with single or multiple polyps.2016

    • Author(s)
      Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y
    • Journal Title

      American Journal of Ophthalmology

      Volume: 166 Pages: 52-59

    • DOI

      10.1016/j.ajo.2016.03.024

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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