| Project/Area Number |
16K20333
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Juntendo University |
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Principal Investigator |
ASADA Yosuke 順天堂大学, 医学部, 助教 (70596626)
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| Research Collaborator |
Matsuda Akira 順天堂大学, 医学部, 准教授 (00312348)
Nakae Susumu 東京大学, 医科学研究所, 准教授 (60450409)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アレルギー性結膜炎 / IL-33 / ILC2 / 自然リンパ球 / 自然免疫 / TSLP / アレルギー / ＩＬＣ２ |
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| Outline of Final Research Achievements |
In this project, we have performed experiments to identify type 2 Innate lymphoid cells (ILC2) in the eye and to analyze their functions. It was found that ILC2 is present in the lacrimal gland and conjunctiva in a mouse model of innate immune system allergic conjunctivitis and plays an important role in the induction of eosinophil infiltration and inflammatory cytokines. It was also found that inflammation can be suppressed by removing ILC2. Furthermore, ILC2 was also found in human conjunctival tissue in allergic conjunctivitis.
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