protective effect for retinal ganglion cell

• Project/Area Number: 16K20341
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: AKIYAMA Goichi 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (00529547)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 緑内障 / 神経保護 / エダラボン / 脳・神経

Outline of Final Research Achievements

We invastigated that intraocular injection of edaravone exerts neuroprotective effects in an ONI model.Sequential in vivo retinal imaging revealed that post-ONI treatment with edaravone was effective for maintaining the retinal structure. We also demonstrated that edaravone suppressed the production of ROS and stress-induced ASK1-p38 MAPK signaling, which leads to RGC survival following ONI（Akiyama et al. IOVS, 2017）.
We also investigated that the effect of ocular hypertension in human surgical procedure（Akiyama et al. Sci Rep, 2016).
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Research Products

• [Journal Article] Edaravone prevents retinal degeneration in adult mice following optic nerve injury. (2017)
  • Author(s): Akiyama G, Azuchi Y, Guo X, Noro T, Kimura A, Harada C, *Namekata K, Harada T
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 58 Issue: 11 Pages: 4908-4914
  • DOI: 10.1167/iovs.17-22250
  • Peer Reviewed
• [Journal Article] Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis. (2017)
  • Author(s): Azuchi, Y., Kimura, A., Guo, X., Akiyama, G., Noro, T., Harada, C., Nishigaki, A., Namekata, K., Harada, T.
  • Journal Title: Neuroscience Letters Volume: 639 Pages: 82-87
  • DOI: 10.1016/j.neulet.2016.12.057
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intraoperative electrophysiological evaluations of macular function during peripheral scleral indentation. (2016)
  • Author(s): Akiyama G, Matsumoto CS, Shinoda K, Terauchi G, Matsumoto H, Watanabe E, Iwata T, Mizota A, Miyake Y.
  • Journal Title: Scientific Reports. Volume: 6 Issue: 1 Pages: 35164-35164
  • DOI: 10.1038/srep35164
  • Peer Reviewed / Open Access
• [Journal Article] Caloric restriction promotes cell survival in a mouse model of normal tension glaucoma. (2016)
  • Author(s): Guo, X., Kimura, A., Azuchi, Y., Akiyama, G., Noro, T., Harada, C., Namekata, K., Harada, T.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 33950-33950
  • DOI: 10.1038/srep33950
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 視神経挫滅モデルマウスにおけるエダラボンの神経保護効果 (2017)
  • Author(s): 秋山悟一、安土ゆり子、行方和彦、原田高幸
  • Organizer: 第121回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2017-04-07
• [Presentation] カロリー制限による正常眼圧緑内障モデルにおける網膜神経節細胞及び視機能の保護 (2017)
  • Author(s): 郭暁麗、木村敦子、安土ゆり子、秋山悟一、野呂隆彦、原田知加子、行方和彦、原田高幸
  • Organizer: 第121回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2017-04-06
• [Presentation] 視神経挫滅モデルマウスにおけるエダラボンの視神経保護効果 (2017)
  • Author(s): 秋山悟一、安土ゆり子、行方和彦、原田高幸
  • Organizer: 日本眼科学会
• [Remarks] 網膜・視神経変性疾患の病態解明と治療法
  • URL: http://www.igakuken.or.jp/retina/