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Elucidation of spontanious regression mechanisms of neuroblastoma

Research Project

Project/Area Number 16K20346
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

Harada Yui  九州大学, 薬学研究院, 助教 (00608507)

Co-Investigator(Renkei-kenkyūsha) KAWAKUBO Naonori  九州大学, 大学病院, 助教 (90711185)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経芽腫 / 自然退縮 / MYCN / 自然抗体 / 免疫 / 小児腫瘍学
Outline of Final Research Achievements

As a result of investigation of spontaneous regression rate using various depletion antibodies using neuroblastoma model mouse (human MYCN Tg mouse), the influence of CD4 positive T cell, CD8 positive T cell, NK cell is negligible It became clear that it was.
On the other hand, there was a positive correlation between natural antibodies produced by B cells in the peritoneal cavity, especially IgM and IgG3 blood levels and spontaneous regression, and it was also confirmed that there had CDC activity. However, it was suggested that these antibodies are useful as biomarkers of regression but are not as effectors thereof. Further examination of the influence of the transitional antibody from the mother is thought to be necessary.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results)

  • [Presentation] Natural antibody against neuroblastoma of the TH-MYCN transgenic mice has CDC activity2017

    • Author(s)
      Naonori Kawakubo, Yui Harada, Minori Ishii, Ryota Souzaki, Yoshiaki Kinoshita, Yoshikazu Yonemitsu and Tomoaki Taguchi
    • Organizer
      Advances in Neuroblastoma Research Association (ANRA)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional analysis of nti-neuroblastoma natural antibody in MYCN transgenic mice2017

    • Author(s)
      川久保尚徳 原田結 石井生 宗崎良太 木下義晶 米満吉和 田口智章
    • Organizer
      日本小児外科学会学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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