• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A function of deep lymphatic system in lymphedema and treatment for the deep lymphatic system

Research Project

Project/Area Number 16K20358
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionOkayama University

Principal Investigator

Shinaoka Akira  岡山大学, 医歯薬学総合研究科, 助教 (90724500)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsリンパ管 / リンパ節 / リンパ浮腫 / 解剖 / リンパ系造影 / 解剖学 / 形成外科学
Outline of Final Research Achievements

The purpose of this study was the showing relationship between lymphatics anatomy and pathophysiology of lymphedema, finally established the strategy of treatment in lymphedema according to anatomical information. At first, new cadaveric dissection techniques with ICG lymphography was established and new contrast medium for cadaveric lymphangiography was developed. This new research technique of lymphatic anatomy showed whole lymphatic vessels in lower limbs and classified into four lymphatic group, and these lymphatic group had relationship with three lymph nodes (one in popliteal and two in inguinal). In lymphedema patients, damage to lymphatic system leaned to a certain lymphatic group in these four lymphatic groups. The changing pattern of lymphatic anatomy in lymphedema brought new strategy of lymphatic surgery.

Academic Significance and Societal Importance of the Research Achievements

リンパ系は心血管系とは別の循環系である。中にはリンパが流れ、免疫や水分を流し調節する役割を担っている。がん治療の際に、切除され放射線が当たることで、リンパ系の機能低下が生じる。ひどくなるとリンパ浮腫を発症するが、詳細な発症機序は不明であり、十分な治療法も存在しない。我々はリンパ系解剖をすすめ、リンパ浮腫の発症原因の一因に深部リンパ系が関係あることを示唆している。今後の治療応用が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2019 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Exercise-Loaded Indocyanine Green Fluorescence Lymphangiography for Diagnosing Lymphedema2019

    • Author(s)
      Matsumoto K, Shinaoka A, Yamada K, Kimata Y
    • Journal Title

      J Reconstr Microsurg

      Volume: 35 Issue: 02 Pages: 138-144

    • DOI

      10.1055/s-0038-1667366

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified Posterolateral Approach for Pterygium Colli2019

    • Author(s)
      Komatsu S, Shinaoka A, Kimata Y
    • Journal Title

      J Craniofac Surg

      Volume: 30 Issue: 1 Pages: 214-217

    • DOI

      10.1097/scs.0000000000005127

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detailed Vascular Anatomy and Flap Harvest Technique of the Serratus Anterior/Rib Composite Flap2019

    • Author(s)
      Matsumoto H, Shinaoka A, Ohtsuka A, Kimata Y
    • Journal Title

      Plast Reconstr Surg

      Volume: 143 Issue: 1 Pages: 115-124

    • DOI

      10.1097/prs.0000000000005087

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Fresh Cadaver Study on Indocyanine Green Fluorescence Lymphography2018

    • Author(s)
      Shinaoka Akira、Koshimune Seijiro、Yamada Kiyoshi、Kumagishi Kanae、Suami Hiroo、Kimata Yoshihiro、Ohtsuka Aiji
    • Journal Title

      Plastic and Reconstructive Surgery

      Volume: 141 Issue: 5 Pages: 1161-1164

    • DOI

      10.1097/prs.0000000000004315

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression.2018

    • Author(s)
      Ohtsuki T, Asano K, Inagaki J, Shinaoka A, Kumagishi-Shinaoka K, Cilek MZ, Hatipoglu OF, Oohashi T, Nishida K, Komatsubara I, Hirohata S.
    • Journal Title

      J Orthop Res

      Volume: 36 Issue: 12 Pages: 3247-3255

    • DOI

      10.1002/jor.24126

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recurrent branch of anterior interosseous artery perforator-based propeller flap for distal forearm injuries: Report of 2 cases2018

    • Author(s)
      Hamada R, Shinaoka A, Sugiyama N, Watanabe T, Miura Y, Kimata Y
    • Journal Title

      Microsurgery

      Volume: 38 Issue: 8 Pages: 917-923

    • DOI

      10.1002/micr.30388

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laser-Assisted Indocyanine Green Angiography Aids in the Reconstruction of Gustilo Grade IIIB Open Lower-Limb Fractures.2017

    • Author(s)
      Koshimune S, Shinaoka A, Ota T, Onoda S, Kimata Y.
    • Journal Title

      J Reconstr Microsurg.

      Volume: 33 Issue: 02 Pages: 143-150

    • DOI

      10.1055/s-0036-1593807

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-Dimensional Imaging of Lymphatic System in Lymphedema Legs Using Interstitial Computed Tomography-lymphography2017

    • Author(s)
      Yamada K, Shinaoka A, Kimata Y.
    • Journal Title

      Acta Medica Okayama

      Volume: 71 Issue: 2 Pages: 171-177

    • DOI

      10.18926/AMO/54986

    • NAID

      120006027004

    • URL

      https://ousar.lib.okayama-u.ac.jp/54986

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ICG蛍光リンパ管造影によるリンパ浮腫診断―解剖研究による検査プロトコールの標準化と読影法について―2018

    • Author(s)
      品岡 玲、山田 潔、大塚愛二、木股 敬裕
    • Organizer
      第16回 日本フットケア学会年次学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] HYBID (HYaluronan-Binding protein Involved in hyaluronan Depolymerization) 遺伝子の炎症性サイトカインによる発現機構解析2017

    • Author(s)
      大月孝志、吉田浩之、品岡玲、熊岸-品岡加苗、メフメット・ゼイネル・チレッキ、オメル・ファルク・ハティポール、稲垣純子、西田圭一郎、岡田保典 、廣畑聡
    • Organizer
      第30回日本軟骨代謝学会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Whole body imaging of subcutaneous lymphatic system using Indocyanine Green Fluorescence lymphography in fresh cadaver2017

    • Author(s)
      Akira shinaoka, seijiro Koshimune, Kiyoshi Yamada, Hiroo Suami, Yoshihiro Kimata
    • Organizer
      26th world congress of lymphology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ICG蛍光リンパ管造影法による皮下リンパ管解剖研究―新鮮遺体を用いて―2017

    • Author(s)
      品岡 玲、越宗 靖二郎、山田 潔、須網 博夫、大塚愛二、木股 敬裕
    • Organizer
      第10回 蛍光Navigation Surgery研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新鮮遺体を用いた皮下リンパ系解剖研究 新規開発近赤外観察装置による 全身イメージングと組織学的解析2017

    • Author(s)
      品岡 玲、越宗 靖二郎、山田 潔、須網 博夫、大塚愛二、木股 敬裕
    • Organizer
      第26回 日本形成外科学会基礎学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット冠状動脈における弾性線維3次元構造の解析2016

    • Author(s)
      楢崎正博、品岡玲、大塚愛二
    • Organizer
      日本解剖学会 第71回中国・四国支部学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
  • [Presentation] 近赤外線イメージングを用いたご遺体の固定方法の改良2016

    • Author(s)
      小見山高明、大杉博幸、品岡玲、大塚愛二
    • Organizer
      日本解剖学会 第71回中国・四国支部学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
  • [Presentation] 変形性膝関節症の治療効果に関する組織学的解析-ラットモデルを用いての検討-2016

    • Author(s)
      熊岸-品岡 加苗、大月孝志、廣畑聡、河村顕治、大塚愛二 、坂田賢一郎、坂田俊輔
    • Organizer
      第29回日本臨床整形外科学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2016-07-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 変形性関節症へのヒアルロン酸投与、いつ投与すべきか?~動物モデルからの知見~2016

    • Author(s)
      大月孝志、品岡玲、熊岸加苗、河野真優美、篠原真歩、浅野恵一、稲垣純子、大橋俊孝、西田圭一郎、廣畑聡
    • Organizer
      第48回日本結合組織学会学術大会
    • Place of Presentation
      長崎
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 映像装置2018

    • Inventor(s)
      品岡 玲
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-218536
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 映像装置・方法2018

    • Inventor(s)
      Akira Shinaoka
    • Industrial Property Rights Holder
      Okayama University
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] リンパ機能を評価する方法2018

    • Inventor(s)
      岡山大学、浜松ホトニクス
    • Industrial Property Rights Holder
      岡山大学、浜松ホトニクス
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report
    • Overseas

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi