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Management of infection in hypothermic therapy: Approach for comprehensive treatment strategy

Research Project

Project/Area Number 16K20384
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionMie University

Principal Investigator

Suzuki Kei  三重大学, 医学部附属病院, 助教 (40585171)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords感染症 / 低体温 / 血液凝固障害 / 救命 / 低体温療法
Outline of Final Research Achievements

This project focused on infections occurred during hypothermia therapy and studied with a view toward to obtain more information regarding “hypothermia-induced infections”. In addition, we aimed to establish effective and realistic diagnostic markers that reflect infections during hypothermia therapy. During the study period, we revealed that patients with hypothermia therapy was susceptible to complications, especially with coagulopathy. Moreover, such coagulopathy deteriorate with secondary infection. In addition, we reported unique infections treated in our intensive care unit.

Academic Significance and Societal Importance of the Research Achievements

敗血症を中心とした重症感染症においては、国際的ガイドラインの整備がすすみ机上では標準的な治療が展開できる準備が整いつつあるものの、個々の症例は多様性に富んでおり、個々の症例を丁寧に解析する必要性がある。また、敗血症診療の質向上のためには、グローバルな視点にたったガイドラインだけではなく、地域での問題点を明らかとし、地域における敗血症診療体制を樹立することが急務であることが示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (32 results)

All 2019 2018 2017 2016

All Journal Article (22 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 22 results,  Open Access: 18 results,  Acknowledgement Compliant: 6 results) Presentation (10 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Clinicopathological features of TAFRO syndrome complicated by acquired hemophilia A and development of cardiopulmonary arrest that were successfully treated with VA-ECMO and tocilizumab2019

    • Author(s)
      Suzuki Kei、Matsumoto Takeshi、Iwashita Yoshiaki、Ishikura Ken、Fujioka Masaki、Wada Hideo、Katayama Naoyuki、Imai Hiroshi
    • Journal Title

      International Journal of Hematology

      Volume: - Issue: 6 Pages: 737-743

    • DOI

      10.1007/s12185-019-02604-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influenza‐associated septic shock accompanied by septic cardiomyopathy that developed in summer and mimicked fulminant myocarditis2019

    • Author(s)
      Fujioka M, Suzuki K, Iwashita Y, Imanaka-Yoshida K, Ito M, Katayama N, Imai H.
    • Journal Title

      Acute Med Sure

      Volume: 6 Issue: 2 Pages: 192-196

    • DOI

      10.1002/ams2.394

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possibility of venoarteriual extracorporeal membranous oxygenator being a bridging therapy for hemodynamic deterioration of pulmonary tumor thrombotic microangiopathy prior to initiating chemotherapy2018

    • Author(s)
      Iwashita Y, Maruyama K. et al.
    • Journal Title

      Medicine

      Volume: 37 Issue: 37 Pages: e12169-e12169

    • DOI

      10.1097/md.0000000000012169

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy2018

    • Author(s)
      Wada H, Matsumoto T, Suzuki K, Imai H, Katayama N, Iba T, Matsumoto M
    • Journal Title

      Thromb J

      Volume: 16 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s12959-018-0168-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sepsis-Associated Encephalopathy with Multiple Microbleeds in Cerebral White Matter.2018

    • Author(s)
      Shindo A, Suzuki K, Iwashita Y, Tomimoto H.
    • Journal Title

      Am J Med.

      Volume: 131 Issue: 7 Pages: e297-e298

    • DOI

      10.1016/j.amjmed.2018.02.012

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Superior mesenteric artery syndrome leading to reversible mucosal gangrene.2017

    • Author(s)
      Uemura S, Suzuki K, Katayama N, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 4 Issue: 3 Pages: 375-376

    • DOI

      10.1002/ams2.283

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Evaluation of the Activated Partial Thromboplastin Time Waveform2017

    • Author(s)
      Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Hasegawa K, Suzuki K, Imai H, Nakatani K, Katayama N
    • Journal Title

      Clin Appl Thromb Hemost

      Volume: Epub Issue: 5 Pages: 764-770

    • DOI

      10.1177/1076029617724230

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Metformin-associated lactic acidosis treated with continuous renal replacement therapy.2017

    • Author(s)
      Nakamura A, Suzuki K, Imai H, Katayama N.
    • Journal Title

      BMJ Case Rep.

      Volume: - Pages: bcr2016218318-bcr2016218318

    • DOI

      10.1136/bcr-2016-218318

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of the Diagnostic Criteria for the Basic Type of DIC Established by the Japanese Society of Thrombosis and Hemostasis.2017

    • Author(s)
      Aota T, Wada H, Fujimoto N, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Uchiyama T, Seki Y, Katayama N.
    • Journal Title

      Clin Appl Thromb Hemost.

      Volume: 印刷中 Issue: 7 Pages: 579-584

    • DOI

      10.1177/1076029616672582

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bacteremia due to Leuconostoc pseudomesenteroides in a Patient with Acute Lymphoblastic Leukemia: Case Report and Review of the Literature.2017

    • Author(s)
      Ino K, Nakase K, Suzuki K, Nakamura A, Fujieda A, Katayama N.
    • Journal Title

      Case Rep Hematol.

      Volume: 印刷中 Pages: 1-4

    • DOI

      10.1155/2016/7648628

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis.2017

    • Author(s)
      Aota T, Wada H, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Asakura H, Okamoto K, Katayama N.
    • Journal Title

      Clin Appl Thromb Hemost.

      Volume: 印刷中 Issue: 6 Pages: 579-584

    • DOI

      10.1177/1076029616654263

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical blindness induced by hepatic encephalopathy: case report and review of published case reports2017

    • Author(s)
      Tagome SC, Yamamoto A, Suzuki K, Katayama N, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 4 Issue: 1 Pages: 109-113

    • DOI

      10.1002/ams2.225

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The valuable diagnosis of DIC and pre-DIC and prediction of a poor outcome by the evaluation of diagnostic criteria for DIC in patients with hematopoietic injury established by the Japanese Society of Thrombosis and Hemostasis2016

    • Author(s)
      Aota T, Wada H, Fujimoto N, Sugimoto K, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Kawasugi K, Madoiwa S, Asakura H, Katayama N
    • Journal Title

      Thromb Res

      Volume: 147 Pages: 80-84

    • DOI

      10.1016/j.thromres.2016.09.028

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Superior mesenteric artery syndrome as a cause of acute pancreatitis.2016

    • Author(s)
      Kojima S, Suzuki K, Katayama N, Imai H.
    • Journal Title

      BMJ Case Rep.

      Volume: - Pages: bcr2016217073-bcr2016217073

    • DOI

      10.1136/bcr-2016-217073

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recurrent SDSE bacteraemia resulting in streptococcal toxic shock syndrome in a patient with Noonan syndrome.2016

    • Author(s)
      Suzuki K, Nakamura A, Ishikura K, Imai H.
    • Journal Title

      BMJ Case Rep.

      Volume: - Pages: bcr2016216092-bcr2016216092

    • DOI

      10.1136/bcr-2016-216092

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of Patient Care with Ventilator-Associated Conditions in Critically Ill Patients: Risk Factor Analysis.2016

    • Author(s)
      Nakahashi S, Yamada T, Ogura T, Nakajima K, Suzuki K, Imai H.
    • Journal Title

      PLoS One.

      Volume: - Issue: 4 Pages: e0153060-e0153060

    • DOI

      10.1371/journal.pone.0153060

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Respiratory failure with hydrothorax due to acute onset pleuroperitoneal communication after upper endoscopy.2016

    • Author(s)
      Suzuki K, Yokohama K, Yamamoto A, Fujioka M, Katayama N, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 3 Issue: 4 Pages: 426-427

    • DOI

      10.1002/ams2.203

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Management of inadvertent vertebral artery injury due to central venous catheterization in a coagulopathic patient.2016

    • Author(s)
      Yamamoto A, Suzuki K, Sakaida H, Suzuki H, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 3 Issue: 3 Pages: 265-267

    • DOI

      10.1002/ams2.177

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Controlled normothermia for a cerebral air embolism complicating computed tomography-guided transthoracic needle biopsy of the lung.2016

    • Author(s)
      Yamamoto A, Suzuki K, Iwashita Y, Yokoyama K, Omori Y, Suzuki H, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 3 Issue: 4 Pages: 411-414

    • DOI

      10.1002/ams2.211

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postmortem diagnosis of massive gastrointestinal bleeding in a patient with aberrant right subclavian artery-esophageal fistula.2016

    • Author(s)
      Watanabe M, Suzuki K, Fujinaga K, Yamamoto A, Fujioka M, Katayama N, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 3 Issue: 2 Pages: 139-142

    • DOI

      10.1002/ams2.136

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use and effectiveness of prothrombin complex concentrate in an emergency department: a review of 15 cases.2016

    • Author(s)
      Suzuki K, Iwashita Y, Enokiya T, Yokoyama K, Fujioka M, Katayama N, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 3 Issue: 2 Pages: 94-100

    • DOI

      10.1002/ams2.141

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of prothrombin complex concentrate for cardiac injury in patients receiving oral anticoagulant therapy.2016

    • Author(s)
      Fujioka M, Suzuki K, Fujii E, Katayama N, Ito M, Imai H.
    • Journal Title

      Acute Med Surg.

      Volume: 3 Issue: 2 Pages: 210-211

    • DOI

      10.1002/ams2.166

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Influenza-associated septic shock accompanied by septic cardiomyopathy2019

    • Author(s)
      Kei Suzuki
    • Organizer
      3rd JSICM-TSCCM Joint Congress
    • Related Report
      2018 Annual Research Report
  • [Presentation] Influenza-associated septic shock accompanied by septic cardiomyopathy2019

    • Author(s)
      Kei Suzuki
    • Organizer
      第93回日本感染症学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regional education program for improvement the outcome by virtue of the proper use of antimicrobials.2018

    • Author(s)
      Kei Suzuki
    • Organizer
      17th Asia-Pacific Congress of Clinical Microbiology and Infection
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] nfluenza-associated septic shock accompanied by septic cardiomyopathy that developed in summer and mimicked fulminant myocarditis (FM)2018

    • Author(s)
      Masaki Fujioka, Kei Suzuki
    • Organizer
      17th Asia-Pacific Congress of Clinical Microbiology and Infection
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Disseminated histoplasmosis achieved long-term survival in an AIDS patient2018

    • Author(s)
      Akihide Nakamura, Kei Suzuki
    • Organizer
      17th Asia-Pacific Congress of Clinical Microbiology and Infection
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 敗血症性ショックを伴うARDS患者に対する当院のECMO戦略2018

    • Author(s)
      岩下義明, 鈴木圭, 江角亮, 池尻薫, 伊藤亜紗実, 佐々木賢, 平本拓也, 行光昌宏, 加藤隆史, 今井寛
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 臨床所見より疑い得たエチレングリコール中毒の1例2018

    • Author(s)
      江角亮, 鈴木圭, 池尻薫, 伊藤亜紗実, 今井寛
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 急性骨髄性白血病に対する化学療法中に合併した敗血症性ARDSに対して、集学的治療にて救命した1例2018

    • Author(s)
      山口貴則, 鈴木圭, 中村彰秀, 岩下義明, 今井寛
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Imaging in sepsis-associated encephalopathy2017

    • Author(s)
      Fujioka M, Shindo A, Suzuki K.
    • Organizer
      international congress of chemotherapy and infection 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非典型的な症状で発症した上腸間膜動脈症候群の2例2017

    • Author(s)
      鈴木圭, 池尻薫, 伊藤亜紗実, 平本拓也, 石倉健, 大森教成, 藤岡正紀, 武田多一, 今井寛
    • Organizer
      第20回日本臨床救急医学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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