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Study on pathogenesis and treatment for immunoparalysis based on enterobacteria

Research Project

Project/Area Number 16K20387
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionMie University

Principal Investigator

Ito Asami  三重大学, 医学部附属病院, 助教 (80740448)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords敗血症 / 免疫麻痺 / 腸内細菌叢 / PD-L1/L2 / Tリンパ球 / エキソソーム / 腸内細菌 / インテグリンリガンド / インテグリン / リンパ球ホーミング / 外傷 / CLPモデルマウス / CLPモデル / Immunoparalysis
Outline of Final Research Achievements

We analyzed the changes in intestinal bacteria during the transition from SIRS in the acute phase of sepsis to immunoparalysis in the late phase, as we focus on the fact that intestinal bacteria regulate the immune function of the body and are involved in the development of various inflammatory diseases. To identify the hypothesis that the internal bacteria activates the decreased immune function, we study the intestinal bacteria in a cecal ligation and puncture (CLP) sepsis model mouse. Furthermore, we investigated the relationship between the patient severity score (SOFA / APACHEII) and soluble PD-L1/L2 in critical patients with sepsis or without sepsis.

Academic Significance and Societal Importance of the Research Achievements

敗血症の免疫麻痺の病態では、アポトーシスの発生、Treg細胞の割合の増加が含まれる。さらにアポトーシスの著しい増加が敗血症性ショック患者で測定され、さらにT細胞および単球上のPD-1発現のアップレギュレーションが伴っている。本研究では免疫麻痺に着目し敗血症急性期のSIRSから晩期のImmunoparalysisへ移行する際にPD-1/PD-L1の関与が敗血症の免疫麻痺に関与しているかことを検討した。さらに、血液脳循環(免疫―脳循環)に着目して、sPD-L1と臓器障害の発生率に相関がないか検討した。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Feasibility of Measuring Face-to-Face Interactions among ICU Healthcare Professionals Using Wearable Sociometric Badges2020

    • Author(s)
      Ito-Masui Asami、Kawamoto Eiji、Nagai Yuki、Takagi Yuto、Ito Mami、Mizutani Noriko、Yano Ken’ichi、Yano Kazuo、Imai Hiroshi、Shimaoka Motomu
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 201 Issue: 2 Pages: 245-247

    • DOI

      10.1164/rccm.201904-0779le

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-adhesive effects of human soluble thrombomodulin and its domains2019

    • Author(s)
      Kawamoto Eiji、Nago Nodoka、Okamoto Takayuki、Gaowa Arong、Masui-Ito Asami、Sakakura Yosuke、Akama Yuichi、Soe Zay Yar、Prajuabjinda Onmanee、Darkwah Samuel、Appiah Michael G.、Myint Phyoe Kyawe、Obeng Gideon、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 511 Issue: 2 Pages: 312-317

    • DOI

      10.1016/j.bbrc.2019.02.041

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Talin-2 regulates integrin functions in exosomes2019

    • Author(s)
      Soe Zay Yar、Prajuabjinda Onmanee、Myint Phyoe Kyawe、Gaowa Arong、Kawamoto Eiji、Park Eun Jeong、Shimaoka Motomu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 512 Issue: 3 Pages: 429-434

    • DOI

      10.1016/j.bbrc.2019.03.027

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrin and PD-1 Ligand Expression on Circulating Extracellular Vesicles in Systemic Inflammatory Response Syndrome and Sepsis2018

    • Author(s)
      Kawamoto Eiji、Masui-Ito Asami、Eguchi Akiko、Soe Zay Yar、Prajuabjinda Onmanee、Darkwah Samuel、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
    • Journal Title

      SHOCK

      Volume: - Issue: 1 Pages: 1-1

    • DOI

      10.1097/shk.0000000000001228

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two cases of life-threatening arrhythmia induced by risperidone: evaluation of risperidone and 9-hydroxy-risperidone concentrations.2017

    • Author(s)
      Ito A, Enokiya T, Kawamoto E, Iwashita Y, Takeda T, Ikemura K, Okuda M, Imai H.
    • Journal Title

      Acute Medicine & Surgery

      Volume: 印刷中 Issue: 3 Pages: 341-343

    • DOI

      10.1002/ams2.277

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tocilizumab for uncontrollable systemic inflammatory response syndrome complicating adult-onset Still disease: Case report and review of literature.2017

    • Author(s)
      Masui-Ito A, Okamoto R, Ikejiri K, Fujimoto M, Tanimura M, Nakamori S, Murata T, Ishikawa E, Yamada N, Imai H, Ito M.
    • Journal Title

      Medicine (Baltimore)

      Volume: 96(29) Issue: 29 Pages: e7596-e7596

    • DOI

      10.1097/md.0000000000007596

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ウェアラブルセンサーを用いたECMO患者の治療を行う医療従事者の職業間コミュニケーション定量化の検証2020

    • Author(s)
      ◎伊藤亜紗実、川本英嗣、奥野郁斗、江角亮、岩下義明、鈴木圭、加藤隆史、行光昌宏、今井寛、島岡要
    • Organizer
      日本集中治療医学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 敗血症性肺障害における2型自然リンパ球の機能解析2020

    • Author(s)
      ◎赤間悠一、朴恩正、佐藤尚子、川本英嗣、伊藤亜紗実、伊藤温志、江角亮、池尻薫、今井寛、島岡要
    • Organizer
      日本集中治療医学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 第XⅢ因子低下による出血傾向を来した体外式膜型人工肺(ECMO)管理下の2症例2019

    • Author(s)
      ◎伊藤亜紗実、鈴木圭、池尻薫、岩下義明、今井寛
    • Organizer
      日本血栓止血学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウェアラブルセンサーを用いたシフトワーカーの睡眠パターンが主観的ウェルビーイングに与える影響に関する調査2019

    • Author(s)
      ◎伊藤亜紗実、江角亮、池尻薫、佐野あかね、川本英嗣、島岡要、今井寛
    • Organizer
      日本救急医学会
    • Related Report
      2019 Annual Research Report
  • [Book] 救急超音波テキスト : point of careとしての実践的活用法2018

    • Author(s)
      亀田徹、木村昭夫、伊藤亜紗実、川本英嗣、今井寛、児玉貴光、山口嘉一、野村岳志、本多英喜、神山直久、紺野啓、尾本きよか、長沼裕子、石田秀明、丹保亜希仁、鈴木昭広、二階哲朗、福原信一、濱野雄二郎、山田直人ら
    • Total Pages
      361
    • Publisher
      中外医学社
    • ISBN
      9784498166028
    • Related Report
      2018 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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