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Bone Marrow-Derived Mononuclear cells therapy can attenuate acute inflammation in Rat Heatstroke.

Research Project

Project/Area Number 16K20390
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

Yutaka Umemura  大阪大学, 医学部附属病院, 医員 (20743561)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords熱中症 / 骨髄移植 / 急性炎症反応症候群 / 幹細胞移植 / 骨髄由来単核球細胞 / 多臓器障害 / 血管内皮障害 / 集中治療医学
Outline of Final Research Achievements

Background: This study was performed to gain insights into novel therapeutic approaches for acute inflammation in heatstroke. Bone marrow-derived mononuclear cells (BMMNCs) secrete anti-inflammatory proteins and have protective effects against acute inflammation. Here, we evaluated whether BMMNCs attenuates systemic inflammation induced by heatstroke.
Methods and Results: Anesthetized Wister rats were subjected to heat stress with/without transplantation of BMMNCs. The control group was administered equal volume of PBS and the sham group underwent the same procedure without heat stress. Seven-day mortality improved significantly in the BMMNCs group versus control group. Transplantation of BMMNCs significantly suppressed induction of pro-inflammatory cytokines, such as IL-6 in the serum after heat stress. Histological analysis revealed that cell infiltration with edema in the lung was evident in the control group, whereas the morphological alteration was ameliorated in BMMNCs group.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Bone Marrow-Derived Mononuclear Cell Therapy Can Attenuate Systemic Inflammation in Rat Heatstroke.2018

    • Author(s)
      Yutaka Umemura
    • Organizer
      47th Critical Care Congress, San Antonio, Texas, USA (February 25-27, 2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 急性炎症病態に対する骨髄由来単核球細胞移植による侵襲制御の可能性2017

    • Author(s)
      梅村 穣
    • Organizer
      第45回日本日本救急医学会総会・学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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