| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Background: This study was performed to gain insights into novel therapeutic approaches for acute inflammation in heatstroke. Bone marrow-derived mononuclear cells (BMMNCs) secrete anti-inflammatory proteins and have protective effects against acute inflammation. Here, we evaluated whether BMMNCs attenuates systemic inflammation induced by heatstroke.
Methods and Results: Anesthetized Wister rats were subjected to heat stress with/without transplantation of BMMNCs. The control group was administered equal volume of PBS and the sham group underwent the same procedure without heat stress. Seven-day mortality improved significantly in the BMMNCs group versus control group. Transplantation of BMMNCs significantly suppressed induction of pro-inflammatory cytokines, such as IL-6 in the serum after heat stress. Histological analysis revealed that cell infiltration with edema in the lung was evident in the control group, whereas the morphological alteration was ameliorated in BMMNCs group.
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