| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The role of endogenous IL-18 in testicular germ cell apoptosis may shift from pro-apoptotic to anti-apoptotic depending on the inflammatory stage by regulating expression of apoptotic mediators and controlling activation of caspase-3, caspase-8, and caspase-9. Leydig cells do not actively synthesize and activate IL-18 despite induction of the immune response under inflammatory conditions. In contrast, a macrophage cell line produced large amounts of IL-18 after LPS stimulation. Our findings support the hypothesis that inflammation leads to an increase in immune-cell-derived IL-18 in the testes and suggest that overproduction of IL-18 during acute inflammatory conditions in vivo may harmful to germ cells and Leydig cells.
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