| Project/Area Number |
16K20394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Juntendo University (2017-2018)
University of the Ryukyus (2016) |
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Principal Investigator |
Kondo Yutaka 順天堂大学, 医学(系)研究科(研究院), 准教授 (90642091)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プリン作動性シグナル / 心肺停止 / 蘇生 / 敗血症 / 集中治療 / AMP / ATP / ミトコンドリア / 人工冬眠 / ミトコンドリア機能 / 救急医学 / 外科 / 侵襲学 / 外傷 |
|---|
| Outline of Final Research Achievements |
AMP could inhibit activation of mitochondrial function. In vivo, AMP could lead to hibernation. AMP may improve survival for cardiac arrest, trauma, and sepsis population.
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| Academic Significance and Societal Importance of the Research Achievements |
AMPは生体内の代謝を抑えることで、心肺停止、外傷、敗血症などの重症病態の予後改善効果が期待できる可能性がある。
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