| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Acute lung injury (ALI) is an inflammatory response of the lungs to both direct and indirect insults such as pneumonia, sepsis, trauma, and highly invasive surgeries, and further progress in prevention and treatment is required.
In this study, an animal experiment was performed to demonstrate the anti-inflammatory effects of an alpha-lipoic acid (ALA) derivative, dihydrolipoyl histidinate zinc complex (DHLHZn) for acute lung injury (ALI) and to investigate the mechanism of action.
LPS were administered intratracheally in the DHLHZn(-) group and the DHLHZn(+) group. Four hours after LPS administration, BALF and lung tissue were collected.Total number of cells, number of neutrophils and lymphocytes, levels of various inflammatory cytokines, and NF-kB p65 concentration of BALF were significantly lower in the DHLHZn(+) group than in the DHLHZn(-) group (p=0.05). Thus, Anti-inflammatory effects of DHLHZn for ALI were demonstrated by BALF and histopathological findings.
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