A new therapeutic strategy for anti-donor specific antigen positive liver transplantation.

Research Project

Project/Area Number	16K20401
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Emergency medicine
Research Institution	Keio University
Principal Investigator	Mizota Takamasa 慶應義塾大学, 医学部(信濃町), 助教 (30649942)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	AMR / DSA / 抗体関連拒絶 / 肝移植 / ＡＭＲ / 抗ドナー抗体
Outline of Final Research Achievements	Outcomes of recipients who had preformed DSA was satisfactory and their DSA turned negative postoperatively. Recipients who developed do novo DSA was poor and AMR occured. Our immunosuppression protocol including portal infusion therapy may be associated with the prevention of AMR and de novo DSA.