| Project/Area Number |
16K20411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | nectin / submandibular gland / ネクチン１ / 唾液腺 / 顎下腺 / 細胞間接着分子 / ネクチン / 細胞間接着 / シグナル伝達 |
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| Outline of Final Research Achievements |
The epithelial cells are linked to each other by cell adhesion molecules that form cell-cell junctions,such as adherens junction(AJ) and tight junction(TJ).The abnormalities of the AJ and TJ components in the salivary gland are associated with the onset of inflammatory diseases or histological abnormalities.We investigated the expression and localization of AJ and TJ components,especially focusing on the localization and roles of nectin family members.The AJ components were located at the apical portion of the boundary between neighboring striated duct cells.Although N1KO submandibular glands were morphologically diminished,There is no significant alteration of the localization of AJs and TJs molecules.The expression level of amylase in the N1KO submandibular glands was lower than that of WT.The serum levels of thyroid hormone thyroxin(T4) were not different between WT and N1KO.Our results suggest that nectins are involved in the maintenance and development of the salivary glands.
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