Interaction between bone and adipose tissue and control of obesity and glucose metabolism through the secretion factors derived from osteoclasts

• Project/Area Number: 16K20413
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: Kyumoto Yukari 九州大学, 歯学研究院, 助教 (40729026)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 破骨細胞 / 脂肪細胞 / 糖代謝 / カテプシンK / 細胞・組織

Outline of Final Research Achievements

Recently, it is reported that interaction between various tissues is involved in the maintenance of homeostasis and development of various disease. We focused on the interaction between bone and adipose tissue and analyzed the effect of the secretion factors derived from osteoclasts (clastokine) on adipocyte differentiation. We showed that cathepsin K, a clastokine, promotes the adipocyte differentiation, and mRNA expression of genes related to insulin resistance changes in pathologically activated osteoclasts induced by IL-1β exposure. Therefore, osteoclasts may play an important role in the interaction between bone and adipose tissue.

Research Products

• [Journal Article] IL-1beta induce pathologically activated osteoclasts bearing extremely high level of resorption activity imaged by pH-sensitive fluorescence probes: A possible pathological subpopulation of osteoclasts, accompanied with suppressed expression of integrin regulating molecule kindling-3 and talin-1. (2018)
  • Author(s): Shiratori T., Kyumoto-Nakamura Y., Kukita A., Uehara N., Zhang J., Koda K., Kamiya M., Badawy T., Tomoda E., Xu X., Yamaza T., Urano Y., Koyano K., Kukita T.
  • Journal Title: J. Immunology Volume: 200 Issue: 1 Pages: 218-228
  • DOI: 10.4049/jimmunol.1602035
  • Peer Reviewed / Int'l Joint Research