| Project/Area Number |
16K20413
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 破骨細胞 / 脂肪細胞 / 糖代謝 / カテプシンK / 細胞・組織 |
|---|
| Outline of Final Research Achievements |
Recently, it is reported that interaction between various tissues is involved in the maintenance of homeostasis and development of various disease. We focused on the interaction between bone and adipose tissue and analyzed the effect of the secretion factors derived from osteoclasts (clastokine) on adipocyte differentiation. We showed that cathepsin K, a clastokine, promotes the adipocyte differentiation, and mRNA expression of genes related to insulin resistance changes in pathologically activated osteoclasts induced by IL-1β exposure. Therefore, osteoclasts may play an important role in the interaction between bone and adipose tissue.
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