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Investigation of immunoreguration mechanism in periodontal disease

Research Project

Project/Area Number 16K20418
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

NARITA Yuka  福岡歯科大学, 口腔歯学部, 助教 (50758050)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords歯周病原細菌 / 獲得免疫 / 病原細菌 / 歯学 / 微生物 / 免疫学
Outline of Final Research Achievements

Periodontal disease is a chronic inflammatory disease caused by oral pathogenic bacteria, and immune response contributes to their onset and progression. The red complex, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola, are most important pathogens in severe periodontitis and co-aggregate with each other for their survival effectively. The immunoresponse of Th17 cells contributes to its clinical condition in periodontitis. Therefore, we conducted a comprehensive analysis how 3 species of the red complex affected T helper cell differentiation. In this study, we identified several cell components of the red complex to induce Th17 differentiation.

Academic Significance and Societal Importance of the Research Achievements

歯周病は国民の多くが罹患する慢性疾患であるが、この口腔疾患が糖尿病などの全身疾患と相互に影響しうる。本研究では、重度の歯周病患者に特徴的に見られる歯周病原細菌に着目し、歯周病病態形成に関わる宿主のヘルパーT細胞Th17を誘導する歯周病原細菌由来の抗原を探索した。微生物と宿主の両側から歯周病発症のメカニズムを明らかにすることで、この成果を将来歯周病ワクチンなどの予防や治療分野に応用可能である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (10 results)

  • [Journal Article] Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis.2018

    • Author(s)
      Tasaki S, Cho T, Nagao JI, Ikezaki S, Narita Y, Arita-Morioka KI, Yasumatsu K, Toyoda K, Kojima H, Tanaka Y.
    • Journal Title

      FEMS Yeast Res.2018 May 1;18(3).

      Volume: 18 Issue: 3 Pages: 1-10

    • DOI

      10.1093/femsyr/foy018

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a major glucose transporter in Flavobacterium johnsoniae: Inhibition of F. johnsoniae colony spreading by glucose uptake.2018

    • Author(s)
      Imamura K, Sato K, Narita Y, Kondo Y, Nakane D, Naito M, Fujiwara T, Nakayama K.
    • Journal Title

      Microbiology and Immunology

      Volume: 62 Issue: 8 Pages: 507-516

    • DOI

      10.1111/1348-0421.12633

    • NAID

      120006987967

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoglobulin-like domains of the cargo proteins are essential for protein stability during secretion by the type IX secretion system.2018

    • Author(s)
      Sato K, Kakuda S, Yukitake H, Kondo Y, Shoji M, Takebe K, Narita Y, Naito M, Nakane D, Abiko Y, Hiratsuka K, Suzuki M, Nakayama K.
    • Journal Title

      Mol Microbiol.

      Volume: 110(1) Issue: 1 Pages: 64-81

    • DOI

      10.1111/mmi.14083

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a Novel Alternatively Spliced Form of Inflammatory Regulator SWAP-70-Like Adapter of T Cells2017

    • Author(s)
      Marie Hashimoto, Jun-ichi Nagao, Shojiro Ikezaki, Sonoko Tasaki, Ken-ichi Arita-Morioka, Yuka Narita, Tamaki Cho, Kenji Yuasa, Amnon Altman, and Yoshihiko Tanaka
    • Journal Title

      International Journal of Inflammation

      Volume: 2017 Pages: 1324735-1324735

    • DOI

      10.1155/2017/1324735

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 歯周病原細菌に対するT細胞応答に関与する抗原タンパク質の同定2018

    • Author(s)
      豊田 馨大、成田 由香、永尾 潤一、有田(森岡)健一、安松香奈江、池崎晶二郎、田崎 園子、長 環、城戸 寛史、田中 芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 歯周病発症に関わるT細胞免疫応答の制御機構の解明2018

    • Author(s)
      永尾 潤一、成田 由香、豊田 馨大、有田(森岡)健一、安松香奈江、池崎晶二郎、田崎 園子、長 環、田中 芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細菌感染がもたらす母体免疫活性化が胎児能システムへ与える影響について2018

    • Author(s)
      安松香奈江、永尾 潤一、豊田 馨大、成田 由香、有田(森岡)健一、池崎 晶二郎、田崎 園子、長 環、城戸 寛史、田中 芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Candida albicans 成分特異的T細胞の病態抑制効果の検討2018

    • Author(s)
      田崎 園子、長 環、永尾 潤一、池崎 晶二郎、成田 由香、有田(森岡)健一、安松 香奈江、豊田 馨大、小島 寛、田中 芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Exploration of a novel T cell antigen of Candida albicans against oral candidiasis2018

    • Author(s)
      Sonoko Tasaki, Tamaki Cho, Jun-ichi Nagao, Yuka Narita, Shojiro Ikezaki, Kanae Yasumatsu, Keita Toyoda, Ken-ichi Arita(Morioka), Hiroshi Kojima, Yoshihiko Tanaka
    • Organizer
      第47回日本免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 実験的歯周炎モデルマウスを用いた病態を惹起する菌体成分の同定2017

    • Author(s)
      成田由香、永尾潤一、有田(森岡)健一、池崎晶二郎、田崎園子、安松香奈江、長環、田中芳彦
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 歯周病病態形成における免疫制御機構の解明2017

    • Author(s)
      永尾潤一、成田由香、有田(森岡)健一、安松香奈江、田崎園子、池崎晶二郎、長環、田中芳彦
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] インプラント細菌汚染モデルを用いた除染効果の検討2017

    • Author(s)
      安松香奈江、成田由香、長環、永尾潤一、有田健一、田崎園子、池崎晶二郎、城戸寛史、田中芳彦
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 歯周病をひきおこす病原微生物の菌体成分の同定2016

    • Author(s)
      成田由香、永尾潤一、田崎園子、有田(森岡)健一、橋本麻利江、池崎晶二郎、 長環、田中芳彦
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 病原微生物による歯周病の免疫学的解析2016

    • Author(s)
      永尾潤一、成田由香、田崎園子、橋本麻利江、池崎晶二郎、有田(森岡)健一、 長環、田中芳彦
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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