Mechanism of increase in brain-aromatic monoamines after peripheral administration of sepiapterin
| Project/Area Number |
16K20429
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OHASHI Akiko 日本大学, 歯学部, 助教 (00571019)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | セロトニン / ドーパミン / モノアミン合成促進 / テトラヒドロビオプテリン補充 / モノアミン合成 / 抗うつ薬 / テトラヒドロビオプテリン / 薬理学 / 脳神経疾患 / 生理活性 / 脳・神経 / モノアミン |
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| Outline of Final Research Achievements |
Serotonin (5HT) biosynthesis in the brain is controlled by tetrahydrobiopterin (BH4) level. Peripheral dosing of sepiapterin (SP) as a prodrug of BH4 to mice showed significant rise in BH4, 5HT, DA and their metabolites in the brain time- and dose-dependently. 5HT synthesis in a culture cell was promoted by added SP in the medium, while more than 20-fold higher concentration of BH4 was required for the same enhancement. SP showed adequate permeation across in vitro BBB model. These results suggested that not-all SP converted to BH4 in the periphery but partly reached the brain as SP.
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Report
(3 results)
Research Products
(9 results)
