• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of pathological mechanism of progressive condylar resorption from the point of view of estrogen and inflammatory cytokine

Research Project

Project/Area Number 16K20434
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku University

Principal Investigator

NOGAMI Shinnosuke  東北大学, 歯学研究科, 助教 (70573575)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords進行性下顎頭吸収 / 顎関節 / 下顎後退症 / 炎症性サイトカイン / エストロゲン
Outline of Final Research Achievements

We compared condylar resorption between ovariectomized and non-ovariectomized rabbits. These rabbit's TMJs were under mechanical stress. The rabbits were allocated into three groups and were sacrificed at 1 week, 2 weeks, and 4weeks. Scores for the area of bone resorption were higher in the ovariectomized group than in non-ovariectomized group. Moreover, scores for the depth of bone resorption were higher in ovariectomized group than those in non-ovariectomized group. For the depth and area in 2 weeks, the largest amount of bone resorption was observed in the ovariectomized group. There were substantially more cells that were positive for tartrate-resistant acid phosphatase in the ovariectomized group than in non-ovariectomized group. These results suggested that estrogen may be related to condylar resorption and repairing mechanism of bone metabolism in TMJs with ovariectomized rabbits was normal.

Academic Significance and Societal Importance of the Research Achievements

本研究は、我が国において難治性疾患の一つに挙げられる、進行性下顎頭吸収( Progrssive Condylar Resorption:PCR)の病態解明を目的としている。実際に臨床で経験したPCR症例は顎関節症の既往があり、さらに低容量ピルの服用をしている女性に多く見られた。顎関節症では復位を伴わない関節円板の前方転位症例がほとんどだった。エストロゲンが下顎頭吸収に関与することは本研究の結果より明らかとなったが、骨代謝の修復機構も働いており、進行性下顎頭吸収の原因は下顎頭に対する過度なメカニカルストレスやエストロゲン以外にも関与していることが示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Experimental comparison between tractional and compressive stress on temporomandibular joint2017

    • Author(s)
      Nogami S Yamauchi K Shimizu Y Hirayama B Kumasaka A Iikubo M Kumamoto H Takahashi T
    • Journal Title

      Oral Dis

      Volume: 23 Issue: 5 Pages: 644-652

    • DOI

      10.1111/odi.12650

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors related to aggressive condylar resorption after orthognathic surgery: a retrospective study.2016

    • Author(s)
      Nogami S, Yamauchi K, Yokota So, Satomi N, Abe-Takata Y, Takahashi T
    • Journal Title

      Journal of Craniomandibular & Sleep Practice

      Volume: 30 Issue: 4 Pages: 1-9

    • DOI

      10.1080/08869634.2016.1201886

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Risk factors related to aggressive condylar resorption after orthognathic surgery for females: retrospective study2018

    • Author(s)
      Nogami S, Yamauchi K, Hachleitner J, Brandner Ch, Enzinger S, Wittig J, Singh D, Takahashi T, Gaggl A
    • Organizer
      Austrian Congress of Oral and Maxillofacial Surgery
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi