| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism of biofilm formation promotion by stress response under the action of low concentration antimicrobial component using in vitro complex biofilm model. After the action of chlorhexidine gluconate (CHG) below the minimum inhibitory concentration (sub-MIC), an increase in the amount of biofilm was observed but no increase in viable count was observed, so that the amount of matrix increased It was inferred. It was suggested that CHG of sub-MIC promotes biofilm formation by influencing the production of extracellular matrix, not bacterial growth in biofilm.
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