| Project/Area Number |
16K20507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 骨補填材料 / 骨補填材 / 歯科インプラント / 歯科補綴学一般 |
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| Outline of Final Research Achievements |
In recent years, researchers have developed and fabricated synthetic bone substitutes to achieve a high relative amount of new bone, while avoiding or minimizing the risks of invasive harvesting of bone from a healthy site, disease transmission and antigenicity. The mechanism of action of materials used for bone regeneration is osteoconduction, which provides a scaffold for enhanced bone tissue growth and formation. A promising technique to increase the bioactivity of carbonate apatite blocks is the addition of osteoinductive growth factors or drugs incorporated into the composite. Statin, a cholesterol-lowering drug, has been shown to have positive effects on bone formation. Additionally, solutions of statin in optimal concentrations could be combined with bone grafts to enhance their regenerative potential.
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