| Project/Area Number |
16K20520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
Aoki Kaori 神奈川歯科大学, 大学院歯学研究科, 助教 (70709229)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 抗菌活性 / シランカップリング剤 / 抗菌性シランカップリング剤 / 歯学 |
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| Outline of Final Research Achievements |
We have synthesized silane coupling agent having a structure of quaternary ammonium salts, named of N-allyl-N-decyl-N-methyl-N-trimethoxysilylpropylammonium iodide (10-I) for the purpose of grant antimicrobial of to the surface of the material. The aim of this study, it was investigated the antibacterial activity to Candida albicans.
As the results, the CFU of the modified group showed a significantly low value. Therefore the surface treatment with 10-I was suggested that 10-I has an effective means of inhibition and prevention of complications of systemic diseases such as aspiration pneumonia as well as dental disease specific bacteria found in the oral cavity, such as an elderly and immune function decline is attributable.
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