Creation of hydrophilic-imparted hard tissue early induction zirconia implant material
| Project/Area Number |
16K20524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナノジルコニア / インプラント / ナノ材料 |
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| Outline of Final Research Achievements |
In recent years, zirconia has been a recognized implant material in clinical dentistry. In the present study, I investigated the performance of an alkali-modified ceria-stabilized tetragonal ZrO2 polycrystalline ceramic-based nanostructured zirconia/alumina composite (NANOZR) implant by assessing surface morphology and composition, wettability, bovine serum albumin adsorption rate, rat bone marrow (RBM) cell attachment, and capacity for inducing bone differentiation. NANOZR surfaces without and with alkali treatment served as the control and test groups, respectively. The alkali-treated NANOZR surface increased ALP activity, OCN production, calcium deposition, and osteogenesis-related gene expression in attached RBM cells. These data suggest that alkali treatment enhances the osteogenesis-inducing capacity of NANOZR implants and may therefore improve their biointegration into alveolar bone.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Osteogenesis-Related Gene Expression on Alkali-Modified NANOZR and Titanium Surfaces with nanonetwork Structures2017
Author(s)
Komasa S, Nishizaki M, Kusumoto T, Terada C, Yin D, Kawamoto A, Yamamoto S, Yoshimine S, Nishizaki H, Shimizu H, Okazaki J, Kawazoe T
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Journal Title
バイオインテグレーション学会雑誌
Volume: 7
Pages: 87-94
NAID
Related Report
Peer Reviewed
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[Journal Article] Influence of titanium surface topography on in vitro differentiation of bone marrow mesenchymal stem cells into osteoblasts2016
Author(s)
Komasa S, Miyake A, Fujio M, Nishizaki M, Taguchi Y, Kusumoto T, Okajima Y, Yoshioka K, Yoshimine S, Yamamoto S, Onti Y, Kon-i H, Nishizaki H, Okazaki J
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Journal Title
バイオインテグレーション学会誌
Volume: 6
Pages: 17-26
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] アメロジェニンコーティングナノ構造析出純チタン金属がインプラント埋入周囲組織に与える影響について2017
Author(s)
寺田知里, 小正 聡, 楠本哲次, 西崎 真理子, Chen L, Yin D, 波床 真依, 藤原到, 吉峰茂樹, 西崎 宏, 小正 裕, 岡崎定司
Organizer
平成29年度日本補綴歯科学会関西支部総会ならびに学術大会
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