| Project/Area Number |
16K20527
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Hiroshima University (2018)
Hiroshima International University (2016-2017) |
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Principal Investigator |
Harada Kana 広島大学, 医系科学研究科(医), 助教 (90609744)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ポリリン酸 / リポポリサッカライド / マクロファージ / CXCL10 / STAT1 / IFN-β / SHP2 / 破骨細胞 / JAK1 / TYK2 / 炎症 / インプラント |
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| Outline of Final Research Achievements |
This study was aimed to examine the effects of polyphosphate [poly(P)], a drug candidate for the treatment of peri-implantitis, on the inflammatory nature of macrophages activated by bacterial lipopolysaccharide (LPS). The results suggest that, in macrophages, poly(P) suppresses LPS-induced phosphorylation of signal transducer and activator of transcription (STAT) 1, a transcriptional factor, through multiple mechanisms including inhibition of the effects of interferon-β and activation of Src homology-2 domain containing protein tyrosine phosphatase. Poly(P) down-regulated STAT1-mediated gene expression such as the gene encoding chemokine (CXC) motif ligand 10. In addition, poly(P) may augment LPS-mediated inhibition of osteoclast differentiation.
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| Academic Significance and Societal Importance of the Research Achievements |
マクロファージにおけるポリリン酸の新たな作用として、IFN-βの作用の抑制やSHP2の活性化を介したSTAT1リン酸化抑制が明らかとなり、ポリリン酸を臨床で用いる上で重要な知見を得ることができた。また、ポリリン酸は生体内にも存在するが、その生理的役割には不明な点が多い。本研究成果は、生体におけるポリリン酸の機能を理解する上でも一助となることが期待される。
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