Development of new bone regeneration therapy using cytokine cocktail derived from dedifferentiated fat cells (DFAT)
Project/Area Number |
16K20541
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dental engineering/Regenerative dentistry
|
Research Institution | Kagoshima University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | DFAT / BMP-9 / 骨再生 / 歯周病 / ADSC / 脱分化脂肪細胞(DFAT) |
Outline of Final Research Achievements |
The purpose of this study was development of new bone regenerative therapy for lost bone tissues due to periodontal and oral disease by using de-differentiated fat cells(DFAT) culture supernatant of bone morphogenetic protein(BMP)-9 and FK506 costimulation. In vitro study demonstrated that BMP-9 and FK506 costimulation induces increase of various cytokine in rat DFAT cells culture supernatant. Furthermore , we demonstrated that rDFAT cells culture supernatant of BMP-9 and FK506 costimulation have bone regenerative potential in rat calvarial defects model.
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Report
(3 results)
Research Products
(14 results)