| Project/Area Number |
16K20543
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨 / BMP / LPS / IL-1 / TGF / 破骨細胞 / 異所性骨形成 / 再生 / 幹細胞 / 骨代謝 / 骨芽細胞 / 再生歯学 / 骨形成 |
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| Outline of Final Research Achievements |
BMP (bone morphogenetic protein) induces ectopic bone formation when it was implanted into the muscle tissues. We found that TGF strongly enhances ectopic bone formation by BMP-2, while LPS inhibits it. From the analysis data, TGF increased the number of osteoblasts and chondrocytes but reduced the number of osteoclasts. On the other hand, LPS reduced the ectopic bone volume less than 50%, but it was failed in IL-1 deficient mice. In addition, IL-1 inhibited the proliferation of the cells obtained from the ectopic bone, suggesting that LPS suppresses ectopic bone formation via IL-1.
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