| Project/Area Number |
16K20550
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯槽骨再生 / 骨再生 / αTCP / 再生医学 |
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| Outline of Final Research Achievements |
Bioabsorbable scaffolds with superior handling characteristics for surgical applications are required, which are replaceable by autologous tissue. We constructed collagen model polypeptides comprising a poly(PHG) made by polycondensation of Pro-Hyp-Gly and porous alpha-tricalcium phosphate sponge as scaffold, by dehydrothermal crosslinking, and examined them on surgically formed canine mandibular bone defects. At 2 and 4 weeks post implantation, bone volumetric densities (VD) for the poly(PHG)/α-TCP group were higher than those for poly(PHG) and no-implant groups. Difference in VD was insignificant among the three groups 8 weeks post-implantation. Histological evaluation 4 weeks post-implantation revealed degraded poly(PHG) and newly formed bone on the α-TCP particle surfaces. At 8 weeks post-implantation, continuous cortical bone formation with Haversian structure was observed in both implant groups. Therefore, this composite can be applied in bone defect treatment.
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