Premetastatic niche formation by circulating tumor endothelial cells
Project/Area Number |
16K20554
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
Maishi Nako 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 腫瘍血管新生 / 腫瘍血管内皮細胞 / 転移 |
Outline of Final Research Achievements |
It is reported the formation of supportive metastatic microenvironment, referred to as premetastatic niche, before arrival of metastatic cells. Tumor endothelial cells, lining tumor blood vessels, is known to circulate in blood. In this study, we investigated the role of TECs in tumor metastasis. TECs adhered lung tissues more compared to normal endothelial cells when they were injected into mice intravenously. We established skin transplantation model using GFP mouse. Tumor cells were injected under the skin graft, and then we detected GFP positive cells in the blood of the mouse. We will examine the mechanisms of tumor metastasis by circulating TECs which secrete many cytokines.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma2017
Author(s)
Torii C., Hida Y., Shindoh M., Akiyama K., Ohga N., Maishi N., Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Sato Y., *Hida K
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Journal Title
Anticancer Res
Volume: 37(3)
Pages: 1219-1225
Related Report
Peer Reviewed
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[Journal Article] Aneuploidy of murine immortalized endothelial cell line, MS12017
Author(s)
Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Umma Habiba, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M.
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Journal Title
J Oral Biosci
Volume: 59
Pages: 50-54
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Tumor endothelial cells express high pentraxin 3 levels.2016
Author(s)
Hida K., Maishi N., Kawamoto T., Akiyama K., Ohga N., Hida Y., Yamada K., Hojo T., Kikuchi H., Sato M., Torii C., Shinohara N., Shindoh M.
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Journal Title
Pathol Int.
Volume: 66(12)
Pages: 687-694
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan.2016
Author(s)
8.Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Nagao-Kitamoto H., Mohammad Towfik Alam, Yamamoto K., Kawamoto T., Inoue N., Taketomi A., Shindoh M., Hida Y., *Hida K.
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Journal Title
Sci Rep.
Volume: 6
Pages: 28039
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 高転移性腫瘍miRによる血管内皮における薬剤耐性誘導2017
Author(s)
間石奈湖, 鳥居ちさほ, 川本泰輔, 森本真弘, 秋山廣輔, 吉岡祐亮, Alam Mohammad Towfik, 南 敬, 落谷孝広, 樋田泰浩, 樋田京子
Organizer
第26回日本がん転移学会学術集会
Related Report
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[Presentation] 尿路上皮癌における抗癌剤治療後の腫瘍血管ABCB1発現亢進2017
Author(s)
菊地 央, 間石奈湖, 秋山廣輔, 森本真弘, 土屋邦彦, 丸山 覚, 安部崇重, 樋田 泰浩, 原林 透, 飴田 要, 松本隆児, 柏木 明, 松野吉宏, 篠原信雄, 樋田京子
Organizer
第26回日本がん転移学会学術集会
Related Report
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[Presentation] Tumor endothelial cells acquire drug resistance by exosomal-miR derived from high metastatic tumor2016
Author(s)
Hida K., Torii C., Maishi N., Morimoto M., Akiyama K., Kawamoto T., Minami T., Yoshioka Y., Mohammad Towfik Alam, Shindoh M., Hida Y., Ochiya T
Organizer
The 19th International Vascular Biology Meeting
Place of Presentation
Sheraton Boston Hotel (USA)
Year and Date
2016-11-02
Related Report
Int'l Joint Research
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[Presentation] P-glycoprotein expression dynamics in tumor blood vessels of urothelial carcinoma during chemotherapy2016
Author(s)
Kikuchi H., Maishi N., Akiyama K., Morimoto M., Yanagiya M., Miyajima N., Tuchiya K., Maruyama S., Abe T., Hida Y., Harabayashi T., Ameda K., Matsumoto R., Kashiwagi A., Demura T., Tsuda M., Tanaka S., Matsuno Y., Shinohara N., Hida K.
Organizer
The 19th International Vascular Biology Meeting
Place of Presentation
Sheraton Boston Hotel (USA)
Year and Date
2016-11-02
Related Report
Int'l Joint Research
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