| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
This study aimed to validate the effect of a novel therapy against BRONJ using local application of bone-marrow derived mesenchymal stem cells (BMMSC) for future clinical applications into human. The BMMSCs were seeded into a few biodegradable scaffolds, and the BMMSCs repopulated in these constructs were planned to transplant into the extraction socket of the BRONJ animal model using rat to examine the therapeutic effects by histopathological study. However, this study failed because the animal model was not able to establish and one of the scaffolds were not obtained. Nonetheless, this study confirmed the efficacy of the “priming of bone regeneration” using HDACi and hypoxic culture to enhance the BMMSC functions for developing tissue-engineered constructs.
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