Elucidation of a molecular network which regulates craniofacial formation
| Project/Area Number |
16K20572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
KOGO Mikihiko
AIKAWA Tomonao
MIYAGAWA Kazuaki
Lanske Beate
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭蓋顎顔面 / 発生生物学 / 部位特的遺伝子改変マウス / Indian hedgehog / Pth1r / 分子機序 / conditional knockout マウス / Ihh / 頭蓋 / 顎顔面 / 発生 / 歯学 / 発生分化 / 遺伝子 |
|---|
| Outline of Final Research Achievements |
Cranium is formed through intramembranous ossification and cranial sutures, which abnormalities lead to several clinical issues such as Cranio-maxillofacial deformity, esthetic problems, malocclusion, and growth retardation of neurocerebral system. While there is a complicated molecular network which regulates craniofacial development, we focused to study the role of Ihh/Pth1r. We have successfully established Prx1-Cre;Ihhfl/fl and Prx1-Cre;Pth1rfl/fl which enables us continuous observation from perinatal to postnatal stage. As a result, we found that Prx1-Cre;Pth1rfl/fl caused severe cranial phenotype.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Klotho expression in osteocytes regulates bone metabolism and controls bone formation.2017
Author(s)
Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B.
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Journal Title
Kidney Int.
Volume: 92【3】
Issue: 3
Pages: 599-611
DOI
Related Report
Peer Reviewed / Int'l Joint Research
