| Project/Area Number |
16K20572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
KOGO Mikihiko
AIKAWA Tomonao
MIYAGAWA Kazuaki
Lanske Beate
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭蓋顎顔面 / 発生生物学 / 部位特的遺伝子改変マウス / Indian hedgehog / Pth1r / 分子機序 / conditional knockout マウス / Ihh / 頭蓋 / 顎顔面 / 発生 / 歯学 / 発生分化 / 遺伝子 |
|---|
| Outline of Final Research Achievements |
Cranium is formed through intramembranous ossification and cranial sutures, which abnormalities lead to several clinical issues such as Cranio-maxillofacial deformity, esthetic problems, malocclusion, and growth retardation of neurocerebral system. While there is a complicated molecular network which regulates craniofacial development, we focused to study the role of Ihh/Pth1r. We have successfully established Prx1-Cre;Ihhfl/fl and Prx1-Cre;Pth1rfl/fl which enables us continuous observation from perinatal to postnatal stage. As a result, we found that Prx1-Cre;Pth1rfl/fl caused severe cranial phenotype.
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