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Elucidation of a molecular network which regulates craniofacial formation

Research Project

Project/Area Number 16K20572
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

AMANO Katsuhiko  大阪大学, 歯学部附属病院, 医員 (20448129)

Research Collaborator KOGO Mikihiko  
AIKAWA Tomonao  
MIYAGAWA Kazuaki  
Lanske Beate  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords頭蓋顎顔面 / 発生生物学 / 部位特的遺伝子改変マウス / Indian hedgehog / Pth1r / 分子機序 / conditional knockout マウス / Ihh / 頭蓋 / 顎顔面 / 発生 / 歯学 / 発生分化 / 遺伝子
Outline of Final Research Achievements

Cranium is formed through intramembranous ossification and cranial sutures, which abnormalities lead to several clinical issues such as Cranio-maxillofacial deformity, esthetic problems, malocclusion, and growth retardation of neurocerebral system. While there is a complicated molecular network which regulates craniofacial development, we focused to study the role of Ihh/Pth1r. We have successfully established Prx1-Cre;Ihhfl/fl and Prx1-Cre;Pth1rfl/fl which enables us continuous observation from perinatal to postnatal stage. As a result, we found that Prx1-Cre;Pth1rfl/fl caused severe cranial phenotype.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results)

  • [Int'l Joint Research] Harvard School of Dental Medicine(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Klotho expression in osteocytes regulates bone metabolism and controls bone formation.2017

    • Author(s)
      Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B.
    • Journal Title

      Kidney Int.

      Volume: 92【3】 Issue: 3 Pages: 599-611

    • DOI

      10.1016/j.kint.2017.02.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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