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The elucidation of stem cell in salivary gland reproduction by using drug

Research Project

Project/Area Number 16K20573
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

Minagi Hitomi  大阪大学, 歯学研究科, 特任研究員 (70754810)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords唾液腺 / 再生医療 / 顎下腺 / ピロカルピン塩酸塩 / 再生
Outline of Final Research Achievements

I analyzed a salivary gland damage - reproduction process for regeneration salivary gland.I reported articles in an authoritative magazine, "Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands" and "Runx1 mediates the development of the granular convoluted tubules in the submandibular glands」

Academic Significance and Societal Importance of the Research Achievements

唾液腺の損傷-再生過程を解析し、臓器再生に応用し治療に生かすための研究基盤を確立することが目的とし研究を遂行した。内容の一部は「Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands」と「Runx1 mediates the development of the granular convoluted tubules in the submandibular glands」として権威ある雑誌に報告した。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands.2018

    • Author(s)
      Minagi HO, Ikai K, Araie T, Sakai M, Sakai T
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 503 Issue: 2 Pages: 1098-1102

    • DOI

      10.1016/j.bbrc.2018.06.125

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Runx1 mediates the development of the granular convoluted tubules in the submandibular glands2017

    • Author(s)
      Ono Minagi Hitomi、Sarper Safiye Esra、Kurosaka Hiroshi、Kuremoto Koh-ichi、Taniuchi Ichiro、Sakai Takayoshi、Yamashiro Takashi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 9 Pages: 0184395-0184395

    • DOI

      10.1371/journal.pone.0184395

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Pilocarpine benefit in stem cell therapy2017

    • Author(s)
      Ono Hitomi
    • Organizer
      Gordon research conference
    • Place of Presentation
      Texas, U.S.A
    • Year and Date
      2017-02-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 唾液腺性差とRunx1cKOマウスの唾液分泌制御機構2017

    • Author(s)
      皆木 瞳
    • Organizer
      歯科基礎医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 口腔乾燥症状に対するピロカルピンの継続的服用の有効性2016

    • Author(s)
      小野 瞳
    • Organizer
      日本基礎歯科医学界
    • Place of Presentation
      札幌コンベンションセンター、札幌、北海道
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-01-27  

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