Development of new articular cartilage reconstruction method using cartilage / bone tissue-inducible hybrid biomaterial

• Project/Area Number: 16K20577
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: Takabatake Kiyofumi 岡山大学, 医歯薬学総合研究科, 助教 (70736537)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ハニカムTCP / 人工生体材料 / 軟骨再生 / 骨再生 / 幾何学的構造 / 骨組織形成 / 軟骨組織形成 / 幾何学構造 / 軟骨形成 / 骨形成 / 生体材料 / 再生医療 / 硬組織再生

Outline of Final Research Achievements

The purpose of this study is to develop a new biomaterial that induces both cartilage tissue and bone tissue in thet part of the knee joint defect. Within the study period, a rabbit knee joint defect model was used to induce hard tissue formation by honeycomb TCP. As a result, in the honeycomb TCP having a pore size of 300 μm, bone tissue formation was observed in the bone tissue corresponding part of the knee joint defect and cartilage tissue formation was found in the cartilage corresponding part.

Academic Significance and Societal Importance of the Research Achievements

変形性関節症等、関節軟骨の障害を伴う疾患は、本国内でおよそ数百万人の患者がいるとされ、高齢化社会に伴い患者数は増加の一途であ理、新規治療法の確立は急務である。本申請課題の研究期間内で得られたのラット動物実験における膝関節欠損部の骨・軟骨再生の研究成果は、この数百万人と言われる患者の潜在的な需要に応えることのできる可能性があり、社会的意義は高いと考えられる。

Research Products

• [Journal Article] Feasible Advantage of Bioactive/Bioresorbable Devices Made of Forged Composites of Hydroxyapatite Particles and Poly-L-lactide in Alveolar Bone Augmentation: A Preliminary Study (2019)
  • Author(s): Sukegawa Shintaro、Kawai Hotaka、Nakano Keisuke、Kanno Takahiro、Takabatake Kiyofumi、Nagatsuka Hitoshi、Furuki Yoshihiko
  • Journal Title: International Journal of Medical Sciences Volume: 16 Issue: 2 Pages: 311-317
  • DOI: 10.7150/ijms.27986
  • Peer Reviewed / Open Access
• [Journal Article] Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma. (2019)
  • Author(s): Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A.
  • Journal Title: International Journal of Oncology Volume: 54（1） Pages: 283-294
  • DOI: 10.3892/ijo.2018.4631
  • NAID: 120006786204
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In Vivo Tissue response of Endodontic Bio-ceramic materials (2019)
  • Author(s): Teresita Romano, Mara Victoria Jammal, Keisuke Nakano, Ana Garca Rusco, Jorge Olmos Fassi, Silvia Kozuszko, Kiyofumi Takabatake, Hitoshi Nagatsuka, Liliana Raquel Missana
  • Journal Title: Journal of Hard Tissue Biology Volume: 28(1) Pages: 1-6
  • NAID: 130007584511
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Notch Signaling Affects Oral Neoplasm Cell Differentiation and Acquisition of Tumor-Specific Characteristics (2019)
  • Author(s): Nakano Keisuke、Takabatake Kiyofumi、Kawai Hotaka、Yoshida Saori、Maeda Hatsuhiko、Kawakami Toshiyuki、Nagatsuka Hitoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 8 Pages: 1973-1973
  • DOI: 10.3390/ijms20081973
  • NAID: 120006765095
  • Peer Reviewed / Open Access
• [Journal Article] Biomechanical Loading Comparison between Titanium and Unsintered Hydroxyapatite/Poly-L-Lactide Plate System for Fixation of Mandibular Subcondylar Fractures (2019)
  • Author(s): Sukegawa Shintaro、Kanno Takahiro、Yamamoto Norio、Nakano Keisuke、Takabatake Kiyofumi、Kawai Hotaka、Nagatsuka Hitoshi、Furuki Yoshihiko
  • Journal Title: Materials Volume: 12 Issue: 9 Pages: 1557-1557
  • DOI: 10.3390/ma12091557
  • NAID: 120006816641
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemistry of YAP and dNp63 and survival analysis of patients bearing precancerous lesion and oral squamous cell carcinoma (2019)
  • Author(s): Ono Sawako、Nakano Keisuke、Takabatake Kiyofumi、Kawai Hotaka、Nagatsuka Hitoshi
  • Journal Title: International Journal of Medical Sciences Volume: 16 Issue: 5 Pages: 766-773
  • DOI: 10.7150/ijms.29995
  • NAID: 120006860083
  • Peer Reviewed / Open Access
• [Journal Article] Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer. (2019)
  • Author(s): Yoshida S, Kawai H, Eguchi T, Sukegawa S, Oo MW, Anqi C, Takabatake K, Nakano K, Okamoto K, Nagatsuka H.
  • Journal Title: Cells. Volume: 8(7). Issue: 7 Pages: 761-761
  • DOI: 10.3390/cells8070761
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differentiation and roles of bone marrow-derived cells on the tumor microenvironment of oral squamous cell carcinoma (2019)
  • Author(s): Anqi C, Takabatake K, Kawai H, Oo MW, Yoshida S, Fujii M, Omori H, Sukegawa S, Nakano K, Tsujigiwa H, Jinhua Z, Nagatsuka H.
  • Journal Title: Oncol Lett Volume: 18(6) Pages: 6628-6638
  • DOI: 10.3892/ol.2019.11045
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide (2019)
  • Author(s): Sukegawa Shintaro、Kawai Hotaka、Nakano Keisuke、Takabatake Kiyofumi、Kanno Takahiro、Nagatsuka Hitoshi、Furuki Yoshihiko
  • Journal Title: Materials Volume: 12 Issue: 22 Pages: 3681-3681
  • DOI: 10.3390/ma12223681
  • NAID: 120006816642
  • Peer Reviewed / Open Access
• [Journal Article] Do the Presence of Mandibular Third Molar and the Occlusal Support Affect the Occurrence and the Mode of Mandibular Condylar Fractures? (2019)
  • Author(s): Shintaro Sukegawa, Masato Saika, Takahiro Kanno, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka, Yoshihiko Furuki
  • Journal Title: Journal of Hard Tissue Biology Volume: 28(4) Pages: 377-382
  • NAID: 130007739009
  • Peer Reviewed / Open Access
• [Journal Article] The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Oral Squamous Cell Carcinoma (2019)
  • Author(s): Takabatake K, Shimo T, Murakami J, Anqi C, Kawai H, Yoshida S, Wathone Oo M, Haruka O, Sukegawa S, Tsujigiwa H, Nakano K, Nagatsuka H.
  • Journal Title: Int J Mol Sci Volume: 20(22) Issue: 22 Pages: 5779-5779
  • DOI: 10.3390/ijms20225779
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] <i>In Vitro</i> Efficacy of CaCO₃ Content in CaTiO₃– CaCO₃ Composites for Bone Growth (2018)
  • Author(s): Rodriguez Andrea Paola, Sanchez Maria Alejandra, Felice Betiana, Zamora Martin Lucas, Tsujigiwa Hidetsugu, Takabatake Kiyofumi, Kawai Hotaka, Nakano Keisuke, Nagatsuka Hitoshi
  • Journal Title: Journal of Hard Tissue Biology Volume: 27 Issue: 3 Pages: 250-256
  • DOI: 10.2485/jhtb.27.250
  • NAID: 130007404132
  • ISSN: 1341-7649, 1880-828X
  • Year and Date: 2018-07-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of the Geometrical Structure of a Honeycomb TCP on Relationship between Bone / Cartilage Formation and Angiogenesis (2018)
  • Author(s): Matsuda Hiroyuki、Takabatake Kiyofumi、Tsujigiwa Hidetsugu、Watanabe Satoko、Ito Satoshi、Kawai Hotaka、Hamada Mei、Yoshida Saori、Nakano Keisuke、Nagatsuka Hitoshi
  • Journal Title: International Journal of Medical Sciences Volume: 15 Issue: 14 Pages: 1582-1590
  • DOI: 10.7150/ijms.28452
  • Peer Reviewed / Open Access
• [Journal Article] Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis (2018)
  • Author(s): Kawai Hotaka、Tsujigiwa Hidetsugu、Siar Chong Huat、Nakano Keisuke、Takabatake Kiyofumi、Fujii Masae、Hamada Mei、Tamamura Ryo、Nagatsuka Hitoshi
  • Journal Title: International Journal of Medical Sciences Volume: 15 Issue: 12 Pages: 1406-1414
  • DOI: 10.7150/ijms.24370
  • Peer Reviewed / Open Access
• [Journal Article] The role of bone marrow-derived cells during ectopic bone formation of mouse femoral muscle in GFP mouse bone marrow transplantation model. (2018)
  • Author(s): Takabatake K, Tsujigiwa H, Song Y, Matsuda H, Kawai H, Fujii M, Hamada M, Nakano K, Kawakami T and Nagatsuka H.
  • Journal Title: Int J Med Sci Volume: 15 Issue: 8 Pages: 748-757
  • DOI: 10.7150/ijms.24605
  • Peer Reviewed / Open Access
• [Journal Article] Possibility of Notch Signaling Role in the Cell Differentiation of Experimentally Induced Periodontal Polyp (2018)
  • Author(s): Saeka Matsuda, keita Moriyama, Masahito Shoumura, Aiko Kida, Hidetsugu Tsujigiwa, Kiyofumi Takabatake, Hotaka Kawai, Keisuke Nakano, Norimasa Okafuji, Naoto Osuga and Toshiyuki Kawakami
  • Journal Title: ournal of Dental and Oral Health Volume: 4 Pages: 1-5
  • Peer Reviewed / Open Access
• [Journal Article] The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma (2018)
  • Author(s): Shoko Yoshida, Tsuyoshi Shimo, Yurika Murase, KiyoFumi Takabatake, Koji Kishimoto, Soichiro Ibaragi, Norie Yoshioka, Tatsuo Okui, Hitoshi Nagatsuka AND Akira Sasaki
  • Journal Title: Anticancer Research Volume: 38 Issue: 2 Pages: 955-962
  • DOI: 10.21873/anticanres.12309
  • Peer Reviewed / Open Access
• [Journal Article] Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma. (2017)
  • Author(s): Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.
  • Journal Title: International Journal of Oncology Volume: 51 Issue: 2 Pages: 625-32
  • DOI: 10.3892/ijo.2017.4050
  • NAID: 120006370695
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oral Squamous Cell Carcinoma-derived Sonic Hedgehog Promotes Angiogenesis (2017)
  • Author(s): Kuroda H, Kurio N, Shimo T, Matsumoto K, Masui M, Takabatake K, Okui T, Ibaragi S, Kunisada Y, Obata K, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A.
  • Journal Title: Anticancer Research Volume: 37 Issue: 12 Pages: 6731-6737
  • DOI: 10.21873/anticanres.12132
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Three-Dimensional Cell Culture at the Frontiers of in Vitro Cancer Research:Present Perspectives (2017)
  • Author(s): Soo Leng Lee, Zainal Ariff Bin Abdul Rahman, Hidetsugu Tsujigiwa, Kiyofumi Takabatake, Keisuke Nakano, Wen Lin Chai, Hitoshi Nagatsuka, Chong Huat Siar
  • Journal Title: Annals of Dentistry, University of Malaya Volume: 23 Pages: 13-22
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma. (2017)
  • Author(s): Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A.
  • Journal Title: Anticancer Research Volume: 37 Issue: 11 Pages: 6119-6123
  • DOI: 10.21873/anticanres.12060
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antibacterial Activity and Biocompability of Zinc Oxide and Graphite Particles as Endodontic Materials (2017)
  • Author(s): Kozuszko, S. N., Sanchez, M. A., de Ferro, M. I. G., Sfer, A. M., Madrid, A. P. M.,Takabatake, K., Nakano, K., Nagatsuka, H., Rodriguez, A. P.
  • Journal Title: Journal of Hard Tissue Biology Volume: 26 Issue: 4 Pages: 311-318
  • DOI: 10.2485/jhtb.26.311
  • NAID: 130006832116
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of Honeycomb TCP-induced Microenvironment on Bone Tissue Regeneration in Craniofacial Area (2016)
  • Author(s): Watanabe S, Takabatake K, Tsujigiwa H, Watanabe T, Tokuyama E, Ito S, Nagatsuka H, Kimata Y.
  • Journal Title: Int J Med Sci Volume: 13(6) Issue: 6 Pages: 466-476
  • DOI: 10.7150/ijms.15560
  • Peer Reviewed / Open Access
• [Journal Article] Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma. (2016)
  • Author(s): Obata K1, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Nagatsuka H, Sasaki A.
  • Journal Title: Anti cancer research Volume: 36(12) Issue: 12 Pages: 6335-6341
  • DOI: 10.21873/anticanres.11230
  • Peer Reviewed / Open Access
• [Journal Article] Novel Midkine Inhibitor iMDK Inhibits Tumor Growth and Angiogenesis in Oral Squamous Cell Carcinoma. (2016)
  • Author(s): Masui M, Okui T, Shimo T, Takabatake K, Fukazawa T, Matsumoto K, Kurio N, Ibaragi S, Naomoto Y, Nagatsuka H, Sasaki A.
  • Journal Title: Anticancer Research Volume: 36 Pages: 2775-2781
  • Peer Reviewed / Open Access
• [Journal Article] The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction. (2016)
  • Author(s): Shimo T, Matsumoto K, Takabatake K, Aoyama E, Takebe Y, Ibaragi S, Okui T, Kurio N, Takada H, Obata K, Pang P, Iwamoto M, Nagatsuka H, Sasaki A.
  • Journal Title: PLoS One. Volume: 11(3) Issue: 3 Pages: e0151731-e0151731
  • DOI: 10.1371/journal.pone.0151731
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions. (2016)
  • Author(s): Matsuda S, Nakano K, Tsujigiwa H, Takabatake K, Okafuji N, Shoumura M, Osuga N, Nagatsuka H and Kawakami T
  • Journal Title: Int J Dent Oral Sci Volume: S9 Pages: 1-7
  • DOI: 10.19070/2377-8075-si09001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Anti-osteoporosis effects of 1,4-dihydroxy-2-naphthoic acid in ovariectomized mice with increasing of bone density (2016)
  • Author(s): Kenichiro Kita, Eiki Yamachika, Masakazu Matsubara, Hidetsugu Tsujigiwa, Nobuhisa Ishida, Norifumi Moritani, Tatsushi Matsumura, Masahide Mizutani, Yuki Fujita, Kiyofumi Takabatake, Kenichiro Ejima, Hitoshi Nagatsuka, Yoshinori Yamaguchi, Seiji Iida
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 28(1) Issue: 1 Pages: 66-72
  • DOI: 10.1016/j.ajoms.2015.07.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] ハニカムTCPの硬組織形成制御機構解明と臨床応用 (2019)
  • Author(s): 大森悠加、高畠清文、辻極秀次、河合穂高、吉田沙織、May wathone Oo、中野敬介、長塚仁
  • Organizer: 第40回岡山歯学会総会・学術大会
• [Presentation] 頭頸部領域再建におけるハニカムTCPの硬組織再生メカニズム解明と臨床応用 (2019)
  • Author(s): 高畠清文、辻極秀次、河合穂高、吉田沙織、大森悠加、中野敬介、川上敏行、長塚仁
  • Organizer: 第28回硬組織再生生物学会学術大会・総会
• [Presentation] ハニカムTCPの幾何学的構造による血管新生を介した選択的骨・軟骨形成制御 (2019)
  • Author(s): 高畠清文、辻極秀次、浜田芽衣、河合穂高、吉田沙織、大森悠加、中野敬介、長塚仁
  • Organizer: 第73回NPO法人 日本口腔科学会学術集会
• [Presentation] ハニカムTCPを用いた硬組織形成制御における血管新生について (2018)
  • Author(s): 松田寛之、高畠清文、辻極秀次、浜田芽衣、河合穂高、吉田沙織、中野敬介、長塚 仁
  • Organizer: 第７２回NPO法人日本口腔科学会学術集会
• [Presentation] 口腔扁平上皮癌における癌間質による腫瘍組織の生物学的性格の制御 (2018)
  • Author(s): 高畠清文、松本 卓、河合穂高、吉田沙織、松田寛之、中野敬介、飯田征二、長塚 仁
  • Organizer: 第４７回（公社）日本口腔外科学会 中国四国支部学術集会
• [Presentation] 肺癌移植マウス高転移臓器における骨髄由来細胞の局在と役割の検討 (2018)
  • Author(s): 河合穂高、辻極秀次、藤井昌江、高畠清文、中野敬介、吉田沙織、浜田芽衣、長塚 仁
  • Organizer: 第１０７回日本病理学会総会
• [Presentation] 肺癌移植マウスを用いた高転移臓器における骨髄由来細胞の局在と役割の検討 (2018)
  • Author(s): 河合穂高、辻極秀次、信長ひかり、高畠清文、中野敬介、長塚 仁
  • Organizer: 第２２回日本がん免疫学会総会
• [Presentation] エナメル上皮腫および間質との相互作用が骨組織におよぼす影響について (2018)
  • Author(s): 澄 文香、阪上峻基、浜田芽衣、高畠清文、長塚 仁、辻極秀次
  • Organizer: 第２７回硬組織再生生物学会学術大会・総会
• [Presentation] 口腔扁平上皮癌における腫瘍間質による腫瘍実質の生物学的性格制御について (2018)
  • Author(s): 高畠清文、河合穂高、吉田沙織、松田寛之、藤井昌江、中野敬介、長塚 仁
  • Organizer: 第２７回硬組織再生生物学会学術大会・総会
• [Presentation] ハニカムTCPの幾何学構造が硬組織形成における血管新生に与える影響について (2018)
  • Author(s): 松田寛之、高畠清文、辻極秀次、河合穂高、吉田沙織、中野敬介、長塚 仁
  • Organizer: 第２７回硬組織再生生物学会学術大会・総会
• [Presentation] 腫瘍移植マウスの高転移臓器における骨髄由来細胞の局在と役割の検討 (2018)
  • Author(s): 河合穂高、辻極秀次、信長ひかり、高畠清文、中野敬介、長塚 仁
  • Organizer: 第２９回日本臨床口腔病理学会 総会・学術大会
• [Presentation] 口腔扁平上皮癌におけるPD-L1発現傾向の臨床病理学的解析 (2018)
  • Author(s): 吉田沙織、浜田芽衣、藤井昌江、河合穂高、高畠清文、中野敬介、長塚 仁
  • Organizer: 第３９回岡山歯学会総会・学術大会
• [Presentation] ハニカムTCPを用いた幾何学構造による骨・軟骨組織再生メカニズムの解明 (2017)
  • Author(s): 高畠清文、辻極秀次、浜田芽衣、松田寛之、中野敬介、長塚 仁
  • Organizer: 第71回口腔科学会学術大会
• [Presentation] 下顎歯肉癌顎骨浸潤部におけるNeurokininBの発現とその役割の検討 (2017)
  • Author(s): 小畑協一、志茂 剛、奥井達雄、高畠清文、松本憲一、高田紘行、伊原木聰一郎、長塚 仁、佐々木朗
  • Organizer: 第35回日本口腔腫瘍学会総会・学術大会
• [Presentation] 口腔扁平上皮癌におけるNeurokininBの役割の検討 (2017)
  • Author(s): 小畑協一、志茂 剛、奥井達雄、高畠清文、松本憲一、伊原木聰一郎、長塚 仁、佐々木朗
  • Organizer: 第71回口腔科学会学術大会
• [Presentation] 口腔扁平上皮癌の癌化過程におけるYAPおよび関連因子の検討 (2017)
  • Author(s): 小野早和子、中野敬介、高畠清文、河合穂高、吉田沙織、浜田芽衣、藤井昌江、信長ひかり、辻極秀次、長塚 仁
  • Organizer: 第106回日本病理学会総会
• [Presentation] 三次元共培養法を用いたエナメル上皮腫細胞および間質細胞の相互作用解析 (2017)
  • Author(s): 浜田芽衣、辻極秀次、Siar Chong Huat、 Lee Soo Leng、高畠清文、中野敬介、長塚 仁
  • Organizer: 第106回日本病理学会総会
• [Presentation] エナメル上皮線維腫における Wntとβ-cateninの発現 (2017)
  • Author(s): 中野敬介、高畠清文、杉田好彦、久保勝俊、前田初彦、川上敏行、長塚 仁
  • Organizer: 第106回日本病理学会総会
• [Presentation] マウス肺癌移植モデルにおける骨髄由来細胞の全身的局在と役割 (2017)
  • Author(s): 河合穂高、辻極秀次、信長ひかり、高畠清文、中野敬介、松田寛之、伏見滋子、長塚 仁
  • Organizer: 第26回 硬組織再生生物学会 学術大会
• [Presentation] 口蓋腫瘍の１例 (2017)
  • Author(s): 高畠清文、中野敬介、河合穂高、浜田芽衣、藤井昌江、内田堅一郎、三島克章、上山吉哉、長塚 仁
  • Organizer: 第28回日本臨床口腔病理学会総会・学術大会
• [Presentation] 上顎前歯部に発生した歯原性角化嚢胞の１例 (2017)
  • Author(s): 喜多憲一郎、山口好則、喜多智映子、目黒敬一郎、高畠清文、長塚 仁、傳 晴光
  • Organizer: 第62回公益社団法人口腔外科学会総会・学術大会
• [Presentation] エナメル上皮線維腫における Wntシグナルと細胞分化 (2017)
  • Author(s): 上田優貴子、中野敬介、高畠清文、吉田和加、杉田好彦、久保勝俊、前田初彦、長塚 仁、川上敏行
  • Organizer: 第62回公益社団法人口腔外科学会総会・学術大会
• [Presentation] GFP骨髄移植マウスの異所性骨形成における骨髄由来細胞の関与について (2016)
  • Author(s): 于淞、高畠清文、辻極秀次、松田寛之、河合穂高、吉田沙織、中野敬介、長塚仁
  • Organizer: 第25回硬組織再生生物学会学術大会・総会
  • Place of Presentation: 東京
  • Year and Date: 2016-08-20
• [Presentation] エナメル上皮腫間質性状とCCNおよびYAPの局在の分析 (2016)
  • Author(s): 浜田芽衣、高畠清文、辻極秀次、藤井昌江、小野早和子、信長ひかり、中野敬介、長塚仁
  • Organizer: 第25回硬組織再生生物学会学術大会・総会
  • Place of Presentation: 東京
  • Year and Date: 2016-08-20
• [Presentation] エナメル上皮線維腫におけるWntの免疫組織化学的検討 (2016)
  • Author(s): 中野敬介、高畠清文、浜田芽衣、藤井昌江、吉田和加、杉田好彦、久保勝俊、前田初彦、川上敏行、長塚仁
  • Organizer: 第27回日本臨床口腔病理学会総会・学術大会
  • Place of Presentation: 広島
  • Year and Date: 2016-08-10
• [Presentation] 異所性骨形成微小環境における骨髄幹細胞の関与 (2016)
  • Author(s): 高畠清文、松田寛之、辻極秀次、于淞、藤井昌江、中野敬介、長塚仁
  • Organizer: 第70回NPO法人日本口腔科学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2016-04-15
• [Presentation] 口腔癌細胞におけるニコチンと上皮成長因子受容体の関連性について (2016)
  • Author(s): 桑島大介、伊原木聡一郎、高畠清文、吉岡徳枝、岸本晃治、志茂剛、長塚仁、佐々木朗
  • Organizer: 第70回NPO法人日本口腔科学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2016-04-15