| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We performed the microRNA (miRNA) array analysis using serum exosome miRNAs obtained from oral squamous cell carcinoma (OSCC) patients and healthy volunteers. As a result, we found that 33 miRNAs were significantly up-regulated and 15 miRNAs were down-regulated more than 3-fold changes in OSCC patients compared to healthy volunteers. Among these miRNAs, exosome miR-6068 was the most up-regulated in OSCC patients. And exosome miR-6068 in the culture medium of OSCC cells also increased. We identified exosome miR-26a as a down-regulated miRNA in OSCC patients. In addition, the expression of miR-26a was also significantly decreased in whole serum and OSCC tissues. Furthermore, miR-26a significantly inhibited the growth of human OSCC cells. These results suggest that miR-26a has potential as a novel biomarker and therapeutic tool for OSCC patients.
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