A study on the expression and function of interleukin-6 in oral squamous cell carcinoma ~its possible involvement in chemotherapeutic resistance~

• Project/Area Number: 16K20584
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: Jinno Teppei 九州大学, 大学病院, 医員 (60755247)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: インターロイキン6 / 口腔扁平上皮癌 / 抗癌剤抵抗性 / インターロイキン 6

Outline of Final Research Achievements

Oral squamous cell carcinoma is one of the most common malignancies arising in oral cavity. Remarkable advancement in reconstructive surgery and diagnostic modalities has improved the survival rate of OSCC patients. However, treatment failure for OSCC patients has lethal potential due to locoregional recurrence and distant metastasis. Recently, possible involvement of IL-6 signaling in the resistance to chemotherapy and radiotherapy has been documented in recent studies. We showed that IL-6 signaling is involved in the progression and treatment resistance of OSCC, and IL-6 expression in cancer cells could be a useful predictive factor of poor response to chemotherapy and radiotherapy and unfavorable prognosis. Furthermore, we showed that the transmission pathway via STAT3 signal plays the important role.

Research Products

• [Journal Article] Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma. (2017)
  • Author(s): Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura
  • Journal Title: Oral Oncology Volume: 75 Pages: 148-157
  • DOI: 10.1016/j.oraloncology.2017.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma. (2017)
  • Author(s): Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Kazunari Oobu, Seiji Nakamura
  • Journal Title: Oncology Letters Volume: 14 Pages: 6735-6743
  • DOI: 10.3892/ol.2017.7066
  • Peer Reviewed / Open Access
• [Journal Article] Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2. (2017)
  • Author(s): Yuma Hashiguchi, Shintaro Kawano, Yuichi Goto, Kaori Yasuda, Naoki Kaneko, Taiki Sakamoto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Hideaki Tanaka, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Tamotsu Kiyoshima, Seiji Nakamura
  • Journal Title: Journal of Cellular Physiology Volume: － Issue: 10 Pages: 6565-6577
  • DOI: 10.1002/jcp.26267
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition. (2017)
  • Author(s): Taiki Sakamoto, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Taichi Hattori, Shoichi Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura
  • Journal Title: Oral Oncology Volume: 69 Pages: 15-25
  • DOI: 10.1016/j.oraloncology.2017.03.019
  • Peer Reviewed / Open Access
• [Journal Article] CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma. (2017)
  • Author(s): Kubota K, Moriyama M, Furukawa S, Rafiul HASM, Maruse Y, Jinno T, Tanaka A, Ohta M, Ishiguro N, Yamauchi M, Sakamoto M, Maehara T, Hayashida JN, Kawano S, Kiyoshima T, Nakamura S.
  • Journal Title: Scientific Reports Volume: 7(1) Issue: 1 Pages: 1755-1755
  • DOI: 10.1038/s41598-017-01661-z
  • Peer Reviewed / Open Access
• [Journal Article] Erratum to: Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: a case report and literature review. (2016)
  • Author(s): Kaneko N, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Sakamoto T, Hashiguchi Y, Iida M, Nakamura S.
  • Journal Title: World Journal of Surgical Oncology Volume: 14(1) Issue: 1 Pages: 161-161
  • DOI: 10.1186/s12957-016-0918-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma (2016)
  • Author(s): Shintaro Kawano, Yanqun Zheng, Kazunari Oobu, Ryota Matsubara, Yuichi Goto, Toru Chikui, Tadamasa Yoshitake, Tamotsu Kiyoshima, Teppei Jinno, Yasuyuki Maruse, Eiji Mitate, Ryoji Kitamura, Hideaki Tanaka, Takeshi Toyoshima, Tsuyoshi Sugiura, Seiji Nakamura
  • Journal Title: Oncology Letters Volume: 11 Issue: 5 Pages: 3369-3376
  • DOI: 10.3892/ol.2016.4411
  • Peer Reviewed / Open Access
• [Presentation] 小唾液腺癌45例の臨床病理学的検討 (2017)
  • Author(s): 服部 多市, 松原 良太, 坂本 泰基, 川野 真太郎, 金子 直樹, 橋口 有真, 神野 哲平, 丸瀬 靖之, 田中 翔一, 大部 一成, 中村 誠司
  • Organizer: 日本口腔科学会
• [Presentation] ARONJの新たな医科歯科連携 ARONJを保存的外科治療でどこまで治せるか (2017)
  • Author(s): 梯 裕恵, 松原 良太, 神野 哲平, 森山 雅文, 山添 淳一, 川野 真太郎, 光安 岳志, 大部 一成, 中村 誠司
  • Organizer: 日本口腔科学会
• [Presentation] 口腔扁平上皮癌におけるkallikrein-related peptidase 6の発現と機能に関する研究 (2017)
  • Author(s): 金子 直樹, 川野 真太郎, 松原 良太, 後藤 雄一, 神野 哲平, 丸瀬 靖之, 坂本 泰基, 橋口 有真, 田中 翔一, 服部 多市, 田中 秀明, 大部 一成, 中村 誠司
  • Organizer: 日本頭頸部癌学会
• [Presentation] 口腔扁平上皮癌の浸潤・遊走におけるΔNp63βを介したWnt5a-Ror2シグナル経路の関与 (2017)
  • Author(s): 坂本 泰基, 川野 真太郎, 松原 良太, 後藤 雄一, 神野 哲平, 丸瀬 靖之, 金子 直樹, 橋口 有真, 服部 多市, 田中 翔一, 大部 一成, 中村 誠司
  • Organizer: 日本頭頸部癌学会
• [Presentation] 口腔扁平上皮癌におけるmiR-205の発現と機能 ΔNp63との関連について (2017)
  • Author(s): 橋口 有真, 川野 真太郎, 後藤 雄一, 松原 良太, 金子 直樹, 坂本 泰基, 神野 哲平, 丸瀬 靖之, 田中 秀明, 服部 多市, 田中 翔一, 中村 誠司
  • Organizer: 日本頭頸部癌学会