| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Oral squamous cell carcinoma is one of the most common malignancies arising in oral cavity. Remarkable advancement in reconstructive surgery and diagnostic modalities has improved the survival rate of OSCC patients. However, treatment failure for OSCC patients has lethal potential due to locoregional recurrence and distant metastasis. Recently, possible involvement of IL-6 signaling in the resistance to chemotherapy and radiotherapy has been documented in recent studies. We showed that IL-6 signaling is involved in the progression and treatment resistance of OSCC, and IL-6 expression in cancer cells could be a useful predictive factor of poor response to chemotherapy and radiotherapy and unfavorable prognosis. Furthermore, we showed that the transmission pathway via STAT3 signal plays the important role.
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