| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The purpose of this study is to develop a therapy for salivary gland hypofunction caused by radiation therapy for head and neck cancer by using exosomes of vasculogenic conditioned-peripheral blood mononuclear cells induced by new culture system.
The ability of angiogenesis was evaluated by the colony forming assay, and it was found that the number of colony increased most when the culture period was five days. Subsequently, exosomes were extracted, localized administration to the atrophic salivary glands revealed some phenomena that could be expected to be therapeutic effects. We currently conduct experiments for the further analysis.
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