| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We found PAUF and ZFAND4 for defining microenvironment of oral cancer. PAUF expression was significantly assocoated with nodal metastasis and poor prognosis of oral cancer. PAUF was also involved in acquisition of proliferation and invasion ability and cisplatin resistance in oral cancer cells.
Furthermore, expression of ZFAND4 was strongly related to nodal and distant metastasis of oral cancer. Cases with high expression of ZFAND4 had a significantly unfavourable prognosis compared with patients with low expression of ZFAND4. Moreover, ZFAND4 overexpression was an independent poor prognostic factor for oral cancer as determined by multivariate analysis.
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