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Analysis of metabolic changes associated with cetuximab resistance in oral squamous cell carcinoma and designing of new treatment

Research Project

Project/Area Number 16K20613
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKeio University

Principal Investigator

Yoshikawa Momoko  慶應義塾大学, 医学部(信濃町), 訪問研究員 (50570967)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCD44v / 口腔扁平上皮癌 / セツキシマブ / セツキシマブ耐性 / CD44v
Outline of Final Research Achievements

Our group established cetuximab-resistant cells by using oral squamous cell carcinoma cells expressing CD44v, which is cancer stem cell marker. We also found that cetuximab-resistant cells had high activity of metabolic pathways different from those of the original cell strain by metabolic analysis. We continue to analyze at the molecular level of the metabolic changes associated with cetuximab resistance, and aim at developing new treatments for cetuximab refractory cases.

Academic Significance and Societal Importance of the Research Achievements

セツキシマブ耐性化に伴う分子機構の解析を行うことで、セツキシマブ不応症例に対する新規治療法の開発および患者個別の治療法の可能性も示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results)

  • [Journal Article] Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells2018

    • Author(s)
      Ouchi T.、Morikawa S.、Shibata S.、Takahashi M.、Yoshikawa M.、Soma T.、Miyashita H.、Muraoka W.、Kameyama K.、Kawana H.、Arima Y.、Saya H.、Okano H.、Nakagawa T.、Asoda S.
    • Journal Title

      J Dent Res

      Volume: ー Issue: 7 Pages: 779-786

    • DOI

      10.1177/0022034518759278

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines2016

    • Author(s)
      Ming Wang, Yutaka Miura, Kenji Tsuchihashi, Kazuki Miyano, Osamu Nagano, Momoko Yoshikawa, Ami Tanabe, Jun Makino, Yuki Mochida, Nobuhiro Nishiyama, Hideyuki Saya, Horacio Cabral, Kazunori Kataoka
    • Journal Title

      Journal of Controlled Release

      Volume: 230 Pages: 26-33

    • DOI

      10.1016/j.jconrel.2016.03.038

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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