The new treatment strategy for lymph node metastasis in oral squamous cell carcinoma - Targeting TAM and CSC
| Project/Area Number |
16K20615
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔がん / リンパ節転移 / 口腔癌 / 癌幹細胞 / CD44 / 腫瘍関連マクロファージ |
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| Outline of Final Research Achievements |
This study aimed to propose new treatment methodology for lymph node metastasis in oral squamous cell carcinoma (OSCC). Especially we focused on CD44, colony stimulating factor-1(CSF-1) and receptor (CSF-1R) expression in the tumor microenvironment in OSCC. Our data showed that CD44 strong expression group was significantly related to locally progressive, lymph node metastasis, and prognosis. However, it did not fine the significantly relation between CSF-1(M-CSF) / CSF-1R and clinicopathological factors. In conclusion CD44 expression in the tumor microenvironment in OSCC might be become the treatment target for prevent the locally progressive, lymph node metastasis.
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| Academic Significance and Societal Importance of the Research Achievements |
この研究は、口腔癌におけるCD44発現と、その活性因子としてcolony stimulating factor-1(CSF-1)とCSF-1Rに着目して検討を行った。結果は、CD44強発現群は、局所進行とリンパ節転移および予後と関連していた。しかし、CSF-1/CSF-1RとCD44発現には関連性を認めなかった。口腔癌微小環境内におけるCD44発現は、腫瘍の増殖・転移を抑制する治療ターゲットになることが示唆された。CD44抑制効果は、抗リンパ節転移効果、腫瘍の高悪性化および治療抵抗性を制御し、口腔癌治療全体に与える影響は非常に大きいことから、今後さらなる活性因子の検討が必要である。
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Report
(7 results)
Research Products
(5 results)
