• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The new treatment strategy for lymph node metastasis in oral squamous cell carcinoma - Targeting TAM and CSC

Research Project

Project/Area Number 16K20615
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Medical University

Principal Investigator

Kono Michihide  東京医科大学, 医学部, 講師 (00421066)

Project Period (FY) 2016-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords口腔がん / リンパ節転移 / 口腔癌 / 癌幹細胞 / CD44 / 腫瘍関連マクロファージ
Outline of Final Research Achievements

This study aimed to propose new treatment methodology for lymph node metastasis in oral squamous cell carcinoma (OSCC). Especially we focused on CD44, colony stimulating factor-1(CSF-1) and receptor (CSF-1R) expression in the tumor microenvironment in OSCC. Our data showed that CD44 strong expression group was significantly related to locally progressive, lymph node metastasis, and prognosis. However, it did not fine the significantly relation between CSF-1(M-CSF) / CSF-1R and clinicopathological factors. In conclusion CD44 expression in the tumor microenvironment in OSCC might be become the treatment target for prevent the locally progressive, lymph node metastasis.

Academic Significance and Societal Importance of the Research Achievements

この研究は、口腔癌におけるCD44発現と、その活性因子としてcolony stimulating factor-1(CSF-1)とCSF-1Rに着目して検討を行った。結果は、CD44強発現群は、局所進行とリンパ節転移および予後と関連していた。しかし、CSF-1/CSF-1RとCD44発現には関連性を認めなかった。口腔癌微小環境内におけるCD44発現は、腫瘍の増殖・転移を抑制する治療ターゲットになることが示唆された。CD44抑制効果は、抗リンパ節転移効果、腫瘍の高悪性化および治療抵抗性を制御し、口腔癌治療全体に与える影響は非常に大きいことから、今後さらなる活性因子の検討が必要である。

Report

(7 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Evaluation of OK-432 Injection Therapy as Possible Primary Treatment of Intraoral Ranula2017

    • Author(s)
      Kono M, Satomi T, Abukawa H, Hasegawa O, Watanabe M, Chikazu D
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 75(2) Issue: 2 Pages: 336-342

    • DOI

      10.1016/j.joms.2016.08.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌におけるCD44発現の検討2018

    • Author(s)
      河野 通秀
    • Organizer
      第36回日本口腔腫瘍学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] The clinicopathological study of M2 macrophages expression in oral squamous cell carcinoma2016

    • Author(s)
      Michihide Kono, Takafumi Satomi, On Hasegawa, Harutsugi Abukawa, Masato Watanabe, Yoko Koga, Daichi Chikazu
    • Organizer
      The 23rd European Association for Cranio Maxillo-Facial Surgery Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔扁平上皮癌におけるマクロファージ発現様式の臨床病理学的検討2016

    • Author(s)
      河野 通秀,里見 貴史,長谷川 温,渡辺 正人,池畑 直樹,榎本 愛,虻川 東嗣,古賀 陽子,近津 大地
    • Organizer
      第40回 日本頭頸部癌学会
    • Place of Presentation
      大宮
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔扁平上皮癌におけるマクロファージ発現様式の臨床病理学的検討2016

    • Author(s)
      河野 通秀,里見 貴史,長谷川 温,渡辺 正人,池畑 直樹,榎本 愛,虻川 東嗣,古賀 陽子,近津 大地
    • Organizer
      第 177回東京医科大学医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi