| Project/Area Number |
16K20616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ICHINOHE Tatsuya 東京歯科大学, 歯学部, 教授 (40184626)
TAZAKI Masakazu 東京歯科大学, 歯学部, 教授 (40155065)
SHIBUKAWA Yoshiyuki 東京歯科大学, 歯学部, 准教授 (30276969)
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| Research Collaborator |
INOUE Hiroyuki
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | P2X7受容体 / 三叉神経 / グリア細胞 / pannexin 1チャネル / ATP受容体 / 細胞間相互作用 / 1次ニューロン / ラット / 歯学 / 生理学 / 脳・神経 |
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| Outline of Final Research Achievements |
Functional expression of P2X7 receptor, which was one of the ionotropic P2X receptors, was observed in neurons and glial cells derived from rat trigeminal ganglion. Compared between P2X7 receptors in neurons and glial cells, electro-physiological properties of both cells was possibly different inferring from sensitivity of P2X7 agonists. Direct neuron-glial interaction in trigeminal ganglion was not observed by mechanical stimulation of single neuron or glial cell. Biphasic inward currents by administration of P2X7 receptor agonist may be elicited by extracellular ATP released via pannexin 1 channel.
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