Search for neuron-glial interaction via extracellular ATP in trigeminal ganglion.
Project/Area Number |
16K20616
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Tokyo Dental College |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
ICHINOHE Tatsuya 東京歯科大学, 歯学部, 教授 (40184626)
TAZAKI Masakazu 東京歯科大学, 歯学部, 教授 (40155065)
SHIBUKAWA Yoshiyuki 東京歯科大学, 歯学部, 准教授 (30276969)
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Research Collaborator |
INOUE Hiroyuki
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | P2X7受容体 / 三叉神経 / グリア細胞 / pannexin 1チャネル / ATP受容体 / 細胞間相互作用 / 1次ニューロン / ラット / 歯学 / 生理学 / 脳・神経 |
Outline of Final Research Achievements |
Functional expression of P2X7 receptor, which was one of the ionotropic P2X receptors, was observed in neurons and glial cells derived from rat trigeminal ganglion. Compared between P2X7 receptors in neurons and glial cells, electro-physiological properties of both cells was possibly different inferring from sensitivity of P2X7 agonists. Direct neuron-glial interaction in trigeminal ganglion was not observed by mechanical stimulation of single neuron or glial cell. Biphasic inward currents by administration of P2X7 receptor agonist may be elicited by extracellular ATP released via pannexin 1 channel.
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Report
(3 results)
Research Products
(33 results)
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[Presentation] Odontoblasts express plasma membrane Ca2+-ATPase 1 and 4.2018
Author(s)
Kimura M, Higashikawa A, Kojima Y, Terashima R, Inoue H, Nagai S, Kamata S, Shimada M, Kuroda H, Ogura K, Mochizuki H, Kouno K, Ando M, Shibukawa Y, Tazaki M.
Organizer
第95回日本生理学会大会
Related Report
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[Presentation] Alkali- and ADP-sensitive store-operated Ca2+ entry (SOCE) mediated by Ca2+ release -activated Ca2+ (CRAC) channels in rat odontoblasts.2017
Author(s)
Maki Kimura, Masaki Sato, Yuki Kojima, Asuka Higashikawa, Yuuta Shiozaki, Ryoichi Satou, Reiko Shigefuji, Miyuki Shimada, Hidetaka Kuroda, Kazuhiro Ogura, Hiroyuki Mochizuki, Kyosuke Kouno, Yoshiyuki Shibukawa, Masakazu Tazaki.
Organizer
第94回日本生理学会
Place of Presentation
浜松市
Year and Date
2017-03-28
Related Report
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[Presentation] Alkali- and ADP-sensitive store-operated Ca2+ entry (SOCE) mediated by Ca2+ release -activated Ca2+ (CRAC) channels in rat odontoblasts.2017
Author(s)
Kimura M, Sato M, Kojima Y, Higashikawa A, Shiozaki Y, Satou R, Shigefuji R, Shimada M, Kuroda H, Ogura K, Mochizuki H, Kouno K, Shibukawa Y, Tazaki M.
Organizer
第94回日本生理学会大会
Related Report
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[Presentation] 帰宅後に悪心・嘔吐を生じた日帰り全身麻酔の3症例.2017
Author(s)
黒田英孝, 高野恵実, 飯嶋和斗, 白澤里佳, 永井諭子, 征矢学, 川口潤, 井出智子, 松木由起子, 松浦信幸, 一戸達也.
Organizer
第34回日本障害者歯科学会総会および学術大会
Related Report
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[Presentation] 当地域口腔保健センターでの日帰り全身麻酔システムの構築.2017
Author(s)
大串圭太, 征矢学, 黒田英孝, 倉持真理子, 鈴木奈穂, 布施亜由美, 福島圭子, 黒田真右, 辻野啓一郎, 新谷誠康, 一戸達也.
Organizer
第34回日本障害者歯科学会総会および学術大会
Related Report
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