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Identification of cervical lymph node metastasis prediction molecular marker of oral squamous cell carcinoma from saliva

Research Project

Project/Area Number 16K20618
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Dental College

Principal Investigator

Sugahara Keisuke  東京歯科大学, 歯学部, 講師 (10506926)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔扁平上皮癌 / メタボローム / 頸部リンパ節転移 / 唾液 / バイオマーカー / メタボローム解析
Outline of Final Research Achievements

The detection of cervical lymph node metastasis is important to a prognostic value. Improvement of the diagnosis precision requires a reliable marker. 25 metabolite showed a statistically significant difference between two groups of the oral patients with squamous cell carcinoma and healthy subject among 499 ionic metabolite as a result that oral patients with squamous cell carcinoma 22 case, healthy subject 21 received metabolic analysis using the saliva. Choline, p-Hydroxyphenylacetic acid, 3-Hydroxybutyric acid was a patient with oral squamous cell carcinoma, and Urea was in particular high level in healthy subjects.3-Hydroxybutyric acid was the metabolite that a past did not have the report for oral squamous cell carcinoma.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (8 results)

  • [Journal Article] Novel condylar repositioning method for 3D-printed models2018

    • Author(s)
      Sugahara K, Katsumi Y, Koyachi M, Koyama Y, Matsunaga S, Odaka K, Abe S, Takano M, Katakura A.
    • Journal Title

      Maxillofac Plast Reconstr Surg.

      Volume: 40 Issue: 1 Pages: 1-4

    • DOI

      10.1186/s40902-018-0143-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness and capability of three dimensional, full high-definition movies for surgical education2017

    • Author(s)
      akano M, Kasahara K, Sugahara K, Watanabe A, Yoshida S, Shibahara T.
    • Journal Title

      Maxillofac Plast Reconstr Surg.

      Volume: 39 Issue: 1 Pages: 1-5

    • DOI

      10.1186/s40902-017-0124-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 解析ソフトを用いた光学機器による口腔粘膜蛍光観察2017

    • Author(s)
      菅原圭亮、太尾英子、別所央城、関根理予、大野啓介、片倉 朗、柴原孝彦
    • Journal Title

      日本口腔診断学会雑誌

      Volume: 30 Pages: 168-175

    • NAID

      130007040173

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腸骨PCBM移植術を併用し再手術を行った下顎骨変治骨折の1例2017

    • Author(s)
      菅原圭亮、伊藤和宏、勝見吉晴、高野正行、齊藤 力、片倉 朗
    • Journal Title

      日本口腔診断学会雑誌

      Volume: 30 Pages: 65-71

    • NAID

      130005666299

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic analysis of the saliva of Japanese patients with oral squamous cell carcinoma2017

    • Author(s)
      Mitsuyoshi Ohshima, Keisuke Sugahara, Kiyohiro Kasahara, Akira Katakura
    • Journal Title

      ONCOLOGY REPORTS

      Volume: 37 Issue: 5 Pages: 2727-2734

    • DOI

      10.3892/or.2017.5561

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Foreign Body in the Right Cheek2017

    • Author(s)
      Keisuke Sugahara, Masahide Koyachi, Akihiro Nishiyama, Teruhide Hoshino, Hiroki Bessho, Kiyohiro Kasahara, and Akira Katakura
    • Journal Title

      Oral Science in Japan 2016

      Volume: 1 Pages: 43-44

    • NAID

      40021176956

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Journal Article] A Case of Osseous Choristoma of the Tongue2017

    • Author(s)
      Keisuke Sugahara, Kazuhiro Ito, Takeaki Shiga*, Masahide Koyachi, Teruhide Hoshino, Akihiro Nishiyama, Hiroki Bessho, Kiyohiro Kasahara and Akira Katakur
    • Journal Title

      Oral Science in Japan 2016

      Volume: 1 Pages: 53-54

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Journal Article] Planning for orthognathic surgery at medical fabrication laboratory in Tokyo Dental College (Fab Lab TDC) Clinical Application of Full-Scale-Model made by 3-Dimensional Ink Jet Printer for Orthognathic Surgery2017

    • Author(s)
      Yoshiharu Katsumi, Keisuke Sugahara, Satoru Matsunaga, Kento Odaka, Keisuke Mitomo, Shinichi Abe, Masahide Koyachi, Kazuhiro Ito, Masayuki Takano, Akira Katakura
    • Journal Title

      Oral Science in Japan 2016

      Volume: 1 Pages: 9-11

    • NAID

      40021176912

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Planning for orthognathic surgery at medical fabrication laboratory in Tokyo Dental College (Fab Lab TDC)2017

    • Author(s)
      Yoshiharu Katsumi, Keisuke Sugahara, Satoru Matsunaga, Kento Odaka, Keisuke Mitomo, Shinichi Abe, Masahide Koyachi, Kazuhiro Ito, Masayuki Takano, Akira Katakura
    • Journal Title

      Oral Science in Japan 2016

      Volume: 1 Pages: 9-11

    • Related Report
      2016 Research-status Report
  • [Presentation] Technical report of new condylar repositioning method in 3D Model2017

    • Author(s)
      Katsumi Y, Sugahara K, Koyachi M, Matsunaga S, Odaka K, Mitomo K, Abe S, Takano M, Katakura A
    • Organizer
      3th JADT
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔粘膜蛍光観察の病理組織学的検証2017

    • Author(s)
      菅原圭亮、太尾英子、別所央城、中島 啓、松坂賢一、片倉 朗
    • Organizer
      第62回 日本口腔外科学会学術大会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔粘膜蛍光観察装置の病理組織学的検証2017

    • Author(s)
      太尾英子,菅原圭亮,別所央城,松坂賢一,片倉 朗
    • Organizer
      第27回 日本口腔内科学会 第30回口腔診断学会 合同学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下顎枝矢状分割術での異常骨折(Bad split)症例の検討2017

    • Author(s)
      菅原圭亮、太尾英子、勝見吉晴、小山 侑、小谷地雅秀、別所央城、笠原清弘、
    • Organizer
      第27回日本顎変形症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Skeletal Class II不正咬合者における顎矯正手術後の下唇知覚障害について2017

    • Author(s)
      小谷地雅秀、西山明宏、菅原圭亮、渡邊 章、笠原清弘、高野正行、柴原孝彦
    • Organizer
      第27回日本顎変形症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔粘膜蛍光観察の病理組織学的検証2016

    • Author(s)
      太尾英子,菅原圭亮,別所央城,松坂賢一,片倉 朗
    • Organizer
      第61回 日本口腔外科学会学術大会・総会
    • Place of Presentation
      幕張
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔粘膜蛍光観察の病理組織学的検証2016

    • Author(s)
      太尾英子,菅原圭亮,別所央城,松坂賢一,片倉 朗
    • Organizer
      第26回 日本口腔内科学会 第29回口腔診断学会 合同学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔扁平上皮癌患者の唾液を用いたメタボローム解析2016

    • Author(s)
      菅原圭亮,別所央城,野村武史,高野伸夫,片倉 朗
    • Organizer
      第40回日本頭頸部癌学会
    • Place of Presentation
      大宮
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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