Identification of cervical lymph node metastasis prediction molecular marker of oral squamous cell carcinoma from saliva
| Project/Area Number |
16K20618
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔扁平上皮癌 / メタボローム / 頸部リンパ節転移 / 唾液 / バイオマーカー / メタボローム解析 |
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| Outline of Final Research Achievements |
The detection of cervical lymph node metastasis is important to a prognostic value. Improvement of the diagnosis precision requires a reliable marker. 25 metabolite showed a statistically significant difference between two groups of the oral patients with squamous cell carcinoma and healthy subject among 499 ionic metabolite as a result that oral patients with squamous cell carcinoma 22 case, healthy subject 21 received metabolic analysis using the saliva. Choline, p-Hydroxyphenylacetic acid, 3-Hydroxybutyric acid was a patient with oral squamous cell carcinoma, and Urea was in particular high level in healthy subjects.3-Hydroxybutyric acid was the metabolite that a past did not have the report for oral squamous cell carcinoma.
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Report
(3 results)
Research Products
(17 results)
