Establishment of iPS cells derived from cleft lip and palate patient and osteogenic differentiation.
| Project/Area Number |
16K20619
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
Kato Hiroshi 東京歯科大学, 歯学部, 非常勤講師 (10755036)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | iPS細胞 / 唇顎口蓋裂 / 骨再生 / 骨芽細胞 / 再生医学 / 細胞・組織 / 歯学 |
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| Outline of Final Research Achievements |
Cleft lip and palate (CLP) patients have alveolar bone defects, they need bone graft that allows maxillary arch continuity. Autogenous particulate cancellous bone and marrow harvested from iliac bone is still the gold standard because of the osteogenic properties. However, it has the risk of complications, we expect less invasive procedures using iPS technology. In this study, I established human iPS cells from a patient with non-syndromic CLP and examined osteogenic differentiation of them. In animal models with iPS cells transplantation, some new bone tissues were observed in the bone defects. It is suggested these cells may contribute to new bone regenerative therapies.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia showed corrected osteoblastic differentiation both in vitro and in vivo.2018
Author(s)
Ooki A, Nakamura T, Onodera S, Hayashi K, Hasegawa D, Kato H, Onda T, Watanabe A, Kosaki K, Nishimura K, Ohtaka M, Nakanishi M, Sakamoto T, Yamaguchi A, Sueishi K, Azuma T
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Journal Title
Stem Cell Research & Therapy
Volume: 9
Pages: 12-12
DOI
Related Report
Peer Reviewed / Open Access
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