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Establishment of iPS cells derived from cleft lip and palate patient and osteogenic differentiation.

Research Project

Project/Area Number 16K20619
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Dental College

Principal Investigator

Kato Hiroshi  東京歯科大学, 歯学部, 非常勤講師 (10755036)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsiPS細胞 / 唇顎口蓋裂 / 骨再生 / 骨芽細胞 / 再生医学 / 細胞・組織 / 歯学
Outline of Final Research Achievements

Cleft lip and palate (CLP) patients have alveolar bone defects, they need bone graft that allows maxillary arch continuity. Autogenous particulate cancellous bone and marrow harvested from iliac bone is still the gold standard because of the osteogenic properties. However, it has the risk of complications, we expect less invasive procedures using iPS technology. In this study, I established human iPS cells from a patient with non-syndromic CLP and examined osteogenic differentiation of them. In animal models with iPS cells transplantation, some new bone tissues were observed in the bone defects. It is suggested these cells may contribute to new bone regenerative therapies.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia showed corrected osteoblastic differentiation both in vitro and in vivo.2018

    • Author(s)
      Ooki A, Nakamura T, Onodera S, Hayashi K, Hasegawa D, Kato H, Onda T, Watanabe A, Kosaki K, Nishimura K, Ohtaka M, Nakanishi M, Sakamoto T, Yamaguchi A, Sueishi K, Azuma T
    • Journal Title

      Stem Cell Res Ther

      Volume: 9 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s13287-017-0754-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] iPS細胞から骨細胞様細胞への分化誘導における活性型ビタミンD3の促進作用2017

    • Author(s)
      加藤 宏
    • Journal Title

      歯科学報

      Volume: 117 Pages: 323-326

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血液由来iPS細胞の樹立と骨芽細胞誘導2017

    • Author(s)
      奥平 貴人, 加藤 宏, 長谷川 大悟, 渡邊 豪士,東 俊文,柴原 孝彦
    • Organizer
      第15回日本再生歯科医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment of iPS cells derived from CLP patient and osteogenic differentiation2016

    • Author(s)
      加藤宏
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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